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Association Between Serum Adipsin Levels and Insulin Resistance in Subjects With Various Degrees of Glucose Intolerance

CONTEXT: The association between adipsin and glucose metabolism in human subjects remains unclear. OBJECTIVE: We investigated the associations between adipsin and insulin resistance/β-cell function in subjects with various degrees of glucose intolerance. DESIGN: Fasting blood samples were collected...

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Autores principales: Wang, Jun-Sing, Lee, Wen-Jane, Lee, I-Te, Lin, Shih-Yi, Lee, Wen-Lieng, Liang, Kae-Woei, Sheu, Wayne Huey-Herng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364621/
https://www.ncbi.nlm.nih.gov/pubmed/30746502
http://dx.doi.org/10.1210/js.2018-00359
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author Wang, Jun-Sing
Lee, Wen-Jane
Lee, I-Te
Lin, Shih-Yi
Lee, Wen-Lieng
Liang, Kae-Woei
Sheu, Wayne Huey-Herng
author_facet Wang, Jun-Sing
Lee, Wen-Jane
Lee, I-Te
Lin, Shih-Yi
Lee, Wen-Lieng
Liang, Kae-Woei
Sheu, Wayne Huey-Herng
author_sort Wang, Jun-Sing
collection PubMed
description CONTEXT: The association between adipsin and glucose metabolism in human subjects remains unclear. OBJECTIVE: We investigated the associations between adipsin and insulin resistance/β-cell function in subjects with various degrees of glucose intolerance. DESIGN: Fasting blood samples were collected for measurements of fasting plasma glucose (FPG), insulin, and adipsin. An oral glucose tolerance test was conducted in subjects with no history of diabetes. SETTING: This study was conducted at a medical center. PATIENTS: We enrolled 240 subjects with no history of diabetes and 80 patients with known type 2 diabetes (T2D) on diet control or metformin monotherapy. MAIN OUTCOME MEASURE: β-cell function and insulin resistance were assessed using the homeostasis model assessment (HOMA-β and HOMA-IR, respectively). RESULTS: Levels of serum adipsin were higher in subjects with normal glucose tolerance (4.0 ± 1.1 µg/mL) or prediabetes (4.0 ± 1.5 µg/mL) compared with subjects with newly diagnosed diabetes (3.8 ± 1.1 µg/mL) or with known T2D on diet control (3.4 ± 1.0 µg/mL) or metformin monotherapy (3.0 ± 1.0 µg/mL, P < 0.001). There was no significant association between adipsin and HOMA-β. In contrast, there was an independent negative association between adipsin and HOMA-IR (β coefficient −0.414, 95% CI −0.720 to −0.109, P = 0.008). The association was more prominent in subjects with a body mass index (BMI) ≥25 kg/m(2) or an FPG ≥100 mg/dL (P interaction < 0.001 and 0.014, respectively). CONCLUSIONS: Serum adipsin levels were negatively associated with insulin resistance, especially in subjects with a BMI ≥25 kg/m(2) or an FPG ≥100 mg/dL.
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spelling pubmed-63646212019-02-11 Association Between Serum Adipsin Levels and Insulin Resistance in Subjects With Various Degrees of Glucose Intolerance Wang, Jun-Sing Lee, Wen-Jane Lee, I-Te Lin, Shih-Yi Lee, Wen-Lieng Liang, Kae-Woei Sheu, Wayne Huey-Herng J Endocr Soc Clinical Research Articles CONTEXT: The association between adipsin and glucose metabolism in human subjects remains unclear. OBJECTIVE: We investigated the associations between adipsin and insulin resistance/β-cell function in subjects with various degrees of glucose intolerance. DESIGN: Fasting blood samples were collected for measurements of fasting plasma glucose (FPG), insulin, and adipsin. An oral glucose tolerance test was conducted in subjects with no history of diabetes. SETTING: This study was conducted at a medical center. PATIENTS: We enrolled 240 subjects with no history of diabetes and 80 patients with known type 2 diabetes (T2D) on diet control or metformin monotherapy. MAIN OUTCOME MEASURE: β-cell function and insulin resistance were assessed using the homeostasis model assessment (HOMA-β and HOMA-IR, respectively). RESULTS: Levels of serum adipsin were higher in subjects with normal glucose tolerance (4.0 ± 1.1 µg/mL) or prediabetes (4.0 ± 1.5 µg/mL) compared with subjects with newly diagnosed diabetes (3.8 ± 1.1 µg/mL) or with known T2D on diet control (3.4 ± 1.0 µg/mL) or metformin monotherapy (3.0 ± 1.0 µg/mL, P < 0.001). There was no significant association between adipsin and HOMA-β. In contrast, there was an independent negative association between adipsin and HOMA-IR (β coefficient −0.414, 95% CI −0.720 to −0.109, P = 0.008). The association was more prominent in subjects with a body mass index (BMI) ≥25 kg/m(2) or an FPG ≥100 mg/dL (P interaction < 0.001 and 0.014, respectively). CONCLUSIONS: Serum adipsin levels were negatively associated with insulin resistance, especially in subjects with a BMI ≥25 kg/m(2) or an FPG ≥100 mg/dL. Endocrine Society 2018-12-21 /pmc/articles/PMC6364621/ /pubmed/30746502 http://dx.doi.org/10.1210/js.2018-00359 Text en Copyright © 2019 Endocrine Society https://creativecommons.org/licenses/by-nc-nd/4.0/ This article has been published under the terms of the Creative Commons Attribution Non-Commercial, No-Derivatives License (CC BY-NC-ND; https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical Research Articles
Wang, Jun-Sing
Lee, Wen-Jane
Lee, I-Te
Lin, Shih-Yi
Lee, Wen-Lieng
Liang, Kae-Woei
Sheu, Wayne Huey-Herng
Association Between Serum Adipsin Levels and Insulin Resistance in Subjects With Various Degrees of Glucose Intolerance
title Association Between Serum Adipsin Levels and Insulin Resistance in Subjects With Various Degrees of Glucose Intolerance
title_full Association Between Serum Adipsin Levels and Insulin Resistance in Subjects With Various Degrees of Glucose Intolerance
title_fullStr Association Between Serum Adipsin Levels and Insulin Resistance in Subjects With Various Degrees of Glucose Intolerance
title_full_unstemmed Association Between Serum Adipsin Levels and Insulin Resistance in Subjects With Various Degrees of Glucose Intolerance
title_short Association Between Serum Adipsin Levels and Insulin Resistance in Subjects With Various Degrees of Glucose Intolerance
title_sort association between serum adipsin levels and insulin resistance in subjects with various degrees of glucose intolerance
topic Clinical Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364621/
https://www.ncbi.nlm.nih.gov/pubmed/30746502
http://dx.doi.org/10.1210/js.2018-00359
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