Improving Treatment Outcome of Pemphigus Vulgaris on Vietnamese Patients by Using Desmoglein Elisa Test

BACKGROUND: Pemphigus Vulgaris (PV) is a chronic disease, is characterized by the presence of flacid bullous in skin and mucosa. There are 2 main autoantibodies against desmoglein3 (Dsg3) and desmoglein1 (Dsg1). AIM: The aims of this study were to evaluate the before and after treatment outcome with...

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Detalles Bibliográficos
Autores principales: Van, Anh Tran Thi, Nguyen, Thuong Van, Huu, Sau Nguyen, Thi, Lan Pham, Minh, Phuong Pham Thi, Huu, NghiDinh, Cam, Van Tran, Huyen, My Le, Nguyet, Minh Vu, Hau, Khang Tran, Gandolfi, Marco, Satolli, Francesca, Feliciani, Claudio, Tirant, Michael, Vojvodic, Aleksandra, Lotti, Torello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2019
Materias:
Clinical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364727/
https://www.ncbi.nlm.nih.gov/pubmed/30745956
http://dx.doi.org/10.3889/oamjms.2019.003
Descripción
Sumario:BACKGROUND: Pemphigus Vulgaris (PV) is a chronic disease, is characterized by the presence of flacid bullous in skin and mucosa. There are 2 main autoantibodies against desmoglein3 (Dsg3) and desmoglein1 (Dsg1). AIM: The aims of this study were to evaluate the before and after treatment outcome with corticosteroid, using Desmoglein ELISA test. METHOD: Forty patients with Pemphigus include 36 PV and 4 PF (28 women, 12 women) were enrolled. The titers of Dsg in pemphigus patients by using ELISA test were done before and 1-month treatment RESULTS: Both anti-Dsg1 and anti-Dsg3 levels were significantly reduced after treatment (P < 0.05). The severity of skin lesions was correlated with anti-Dsg1 antibody level and the severity of oral lesions was significantly correlated with anti-Dsg 3 antibody levels (p < 0.05) CONCLUSION: It is recommended that we can predict and improve the outcome of treatment by using Desmoglein ELISA test.

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