Rapid task-dependent tuning of the mouse olfactory bulb

Adapting neural representation to rapidly changing behavioural demands is a key challenge for the nervous system. Here, we demonstrate that the output of the primary olfactory area of the mouse, the olfactory bulb, is already a target of dynamic and reproducible modulation. The modulation depends on...

Descripción completa

Detalles Bibliográficos
Autores principales: Koldaeva, Anzhelika, Schaefer, Andreas T, Fukunaga, Izumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365054/
https://www.ncbi.nlm.nih.gov/pubmed/30724732
http://dx.doi.org/10.7554/eLife.43558
_version_ 1783393360199811072
author Koldaeva, Anzhelika
Schaefer, Andreas T
Fukunaga, Izumi
author_facet Koldaeva, Anzhelika
Schaefer, Andreas T
Fukunaga, Izumi
author_sort Koldaeva, Anzhelika
collection PubMed
description Adapting neural representation to rapidly changing behavioural demands is a key challenge for the nervous system. Here, we demonstrate that the output of the primary olfactory area of the mouse, the olfactory bulb, is already a target of dynamic and reproducible modulation. The modulation depends on the stimulus tuning of a given neuron, making olfactory responses more discriminable through selective amplification in a demand-specific way.
format Online
Article
Text
id pubmed-6365054
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher eLife Sciences Publications, Ltd
record_format MEDLINE/PubMed
spelling pubmed-63650542019-02-07 Rapid task-dependent tuning of the mouse olfactory bulb Koldaeva, Anzhelika Schaefer, Andreas T Fukunaga, Izumi eLife Neuroscience Adapting neural representation to rapidly changing behavioural demands is a key challenge for the nervous system. Here, we demonstrate that the output of the primary olfactory area of the mouse, the olfactory bulb, is already a target of dynamic and reproducible modulation. The modulation depends on the stimulus tuning of a given neuron, making olfactory responses more discriminable through selective amplification in a demand-specific way. eLife Sciences Publications, Ltd 2019-02-06 /pmc/articles/PMC6365054/ /pubmed/30724732 http://dx.doi.org/10.7554/eLife.43558 Text en © 2019, Koldaeva et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Koldaeva, Anzhelika
Schaefer, Andreas T
Fukunaga, Izumi
Rapid task-dependent tuning of the mouse olfactory bulb
title Rapid task-dependent tuning of the mouse olfactory bulb
title_full Rapid task-dependent tuning of the mouse olfactory bulb
title_fullStr Rapid task-dependent tuning of the mouse olfactory bulb
title_full_unstemmed Rapid task-dependent tuning of the mouse olfactory bulb
title_short Rapid task-dependent tuning of the mouse olfactory bulb
title_sort rapid task-dependent tuning of the mouse olfactory bulb
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365054/
https://www.ncbi.nlm.nih.gov/pubmed/30724732
http://dx.doi.org/10.7554/eLife.43558
work_keys_str_mv AT koldaevaanzhelika rapidtaskdependenttuningofthemouseolfactorybulb
AT schaeferandreast rapidtaskdependenttuningofthemouseolfactorybulb
AT fukunagaizumi rapidtaskdependenttuningofthemouseolfactorybulb

Ejemplares similares