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Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
In this trans-ethnic multi-omic study we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenome, and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in GWASs of systolic, diastolic and puls...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365102/ https://www.ncbi.nlm.nih.gov/pubmed/30578418 http://dx.doi.org/10.1038/s41588-018-0303-9 |
| _version_ | 1783393366759702528 |
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| author | Giri, Ayush Hellwege, Jacklyn N. Keaton, Jacob M. Park, Jihwan Qiu, Chengxiang Warren, Helen R. Torstenson, Eric S. Kovesdy, Csaba P. Sun, Yan V. Wilson, Otis D. Robinson-Cohen, Cassianne Roumie, Christianne L. Chung, Cecilia P. Birdwell, Kelly A. Damrauer, Scott M. DuVall, Scott L. Klarin, Derek Cho, Kelly Wang, Yu Evangelou, Evangelos Cabrera, Claudia P. Wain, Louise V. Shrestha, Rojesh Mautz, Brian S. Akwo, Elvis A. Sargurupremraj, Muralidharan Debette, Stéphanie Boehnke, Michael Scott, Laura J. Luan, Jian’an Jing-Hua, Zhao Willems, Sara M. Thériault, Sébastien Shah, Nabi Oldmeadow, Christopher Almgren, Peter Li-Gao, Ruifang Verweij, Niek Boutin, Thibaud S. Mangino, Massimo Ntalla, Ioanna Feofanova, Elena Surendran, Praveen Cook, James P. Karthikeyan, Savita Lahrouchi, Najim Liu, Chunyu Sepúlveda, Nuno Richardson, Tom G. Kraja, Aldi Amouyel, Philippe Farrall, Martin Poulter, Neil R. Laakso, Markku Zeggini, Eleftheria Sever, Peter Scott, Robert A. Langenberg, Claudia Wareham, Nicholas J. Conen, David Alexander Palmer, Colin Neil Attia, John Chasman, Daniel I. Ridker, Paul M. Melander, Olle Mook-Kanamori, Dennis Owen van der Harst, Pim Cucca, Francesco Schlessinger, David Hayward, Caroline Spector, Tim D. Marjo-Riitta, Jarvelin Hennig, Branwen J. Timpson, Nicholas J. Wei-Qi, Wei Smith, Joshua C. Xu, Yaomin Matheny, Michael E. Siew, Edward E. Lindgren, Cecilia Karl-Heinz, Herzig Dedoussis, George Denny, Joshua C. Psaty, Bruce M. Howson, Joanna M. M. Munroe, Patricia B. Newton-Cheh, Christopher Caulfield, Mark J. Elliott, Paul Gaziano, J. Michael Concato, John Wilson, Peter W.F. Tsao, Philip S. Velez Edwards, Digna R. Susztak, Katalin O’Donnell, Christopher J. Hung, Adriana M. Edwards, Todd L. |
| author_facet | Giri, Ayush Hellwege, Jacklyn N. Keaton, Jacob M. Park, Jihwan Qiu, Chengxiang Warren, Helen R. Torstenson, Eric S. Kovesdy, Csaba P. Sun, Yan V. Wilson, Otis D. Robinson-Cohen, Cassianne Roumie, Christianne L. Chung, Cecilia P. Birdwell, Kelly A. Damrauer, Scott M. DuVall, Scott L. Klarin, Derek Cho, Kelly Wang, Yu Evangelou, Evangelos Cabrera, Claudia P. Wain, Louise V. Shrestha, Rojesh Mautz, Brian S. Akwo, Elvis A. Sargurupremraj, Muralidharan Debette, Stéphanie Boehnke, Michael Scott, Laura J. Luan, Jian’an Jing-Hua, Zhao Willems, Sara M. Thériault, Sébastien Shah, Nabi Oldmeadow, Christopher Almgren, Peter Li-Gao, Ruifang Verweij, Niek Boutin, Thibaud S. Mangino, Massimo Ntalla, Ioanna Feofanova, Elena Surendran, Praveen Cook, James P. Karthikeyan, Savita Lahrouchi, Najim Liu, Chunyu Sepúlveda, Nuno Richardson, Tom G. Kraja, Aldi Amouyel, Philippe Farrall, Martin Poulter, Neil R. Laakso, Markku Zeggini, Eleftheria Sever, Peter Scott, Robert A. Langenberg, Claudia Wareham, Nicholas J. Conen, David Alexander Palmer, Colin Neil Attia, John Chasman, Daniel I. Ridker, Paul M. Melander, Olle Mook-Kanamori, Dennis Owen van der Harst, Pim Cucca, Francesco Schlessinger, David Hayward, Caroline Spector, Tim D. Marjo-Riitta, Jarvelin Hennig, Branwen J. Timpson, Nicholas J. Wei-Qi, Wei Smith, Joshua C. Xu, Yaomin Matheny, Michael E. Siew, Edward E. Lindgren, Cecilia Karl-Heinz, Herzig Dedoussis, George Denny, Joshua C. Psaty, Bruce M. Howson, Joanna M. M. Munroe, Patricia B. Newton-Cheh, Christopher Caulfield, Mark J. Elliott, Paul Gaziano, J. Michael Concato, John Wilson, Peter W.F. Tsao, Philip S. Velez Edwards, Digna R. Susztak, Katalin O’Donnell, Christopher J. Hung, Adriana M. Edwards, Todd L. |
| author_sort | Giri, Ayush |
| collection | PubMed |
| description | In this trans-ethnic multi-omic study we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenome, and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in GWASs of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically-predicted gene expression of 840 genes in 45 tissues, and murine renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells. |
| format | Online Article Text |
| id | pubmed-6365102 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-63651022019-06-21 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals Giri, Ayush Hellwege, Jacklyn N. Keaton, Jacob M. Park, Jihwan Qiu, Chengxiang Warren, Helen R. Torstenson, Eric S. Kovesdy, Csaba P. Sun, Yan V. Wilson, Otis D. Robinson-Cohen, Cassianne Roumie, Christianne L. Chung, Cecilia P. Birdwell, Kelly A. Damrauer, Scott M. DuVall, Scott L. Klarin, Derek Cho, Kelly Wang, Yu Evangelou, Evangelos Cabrera, Claudia P. Wain, Louise V. Shrestha, Rojesh Mautz, Brian S. Akwo, Elvis A. Sargurupremraj, Muralidharan Debette, Stéphanie Boehnke, Michael Scott, Laura J. Luan, Jian’an Jing-Hua, Zhao Willems, Sara M. Thériault, Sébastien Shah, Nabi Oldmeadow, Christopher Almgren, Peter Li-Gao, Ruifang Verweij, Niek Boutin, Thibaud S. Mangino, Massimo Ntalla, Ioanna Feofanova, Elena Surendran, Praveen Cook, James P. Karthikeyan, Savita Lahrouchi, Najim Liu, Chunyu Sepúlveda, Nuno Richardson, Tom G. Kraja, Aldi Amouyel, Philippe Farrall, Martin Poulter, Neil R. Laakso, Markku Zeggini, Eleftheria Sever, Peter Scott, Robert A. Langenberg, Claudia Wareham, Nicholas J. Conen, David Alexander Palmer, Colin Neil Attia, John Chasman, Daniel I. Ridker, Paul M. Melander, Olle Mook-Kanamori, Dennis Owen van der Harst, Pim Cucca, Francesco Schlessinger, David Hayward, Caroline Spector, Tim D. Marjo-Riitta, Jarvelin Hennig, Branwen J. Timpson, Nicholas J. Wei-Qi, Wei Smith, Joshua C. Xu, Yaomin Matheny, Michael E. Siew, Edward E. Lindgren, Cecilia Karl-Heinz, Herzig Dedoussis, George Denny, Joshua C. Psaty, Bruce M. Howson, Joanna M. M. Munroe, Patricia B. Newton-Cheh, Christopher Caulfield, Mark J. Elliott, Paul Gaziano, J. Michael Concato, John Wilson, Peter W.F. Tsao, Philip S. Velez Edwards, Digna R. Susztak, Katalin O’Donnell, Christopher J. Hung, Adriana M. Edwards, Todd L. Nat Genet Article In this trans-ethnic multi-omic study we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenome, and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in GWASs of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically-predicted gene expression of 840 genes in 45 tissues, and murine renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells. 2018-12-21 2019-01 /pmc/articles/PMC6365102/ /pubmed/30578418 http://dx.doi.org/10.1038/s41588-018-0303-9 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Giri, Ayush Hellwege, Jacklyn N. Keaton, Jacob M. Park, Jihwan Qiu, Chengxiang Warren, Helen R. Torstenson, Eric S. Kovesdy, Csaba P. Sun, Yan V. Wilson, Otis D. Robinson-Cohen, Cassianne Roumie, Christianne L. Chung, Cecilia P. Birdwell, Kelly A. Damrauer, Scott M. DuVall, Scott L. Klarin, Derek Cho, Kelly Wang, Yu Evangelou, Evangelos Cabrera, Claudia P. Wain, Louise V. Shrestha, Rojesh Mautz, Brian S. Akwo, Elvis A. Sargurupremraj, Muralidharan Debette, Stéphanie Boehnke, Michael Scott, Laura J. Luan, Jian’an Jing-Hua, Zhao Willems, Sara M. Thériault, Sébastien Shah, Nabi Oldmeadow, Christopher Almgren, Peter Li-Gao, Ruifang Verweij, Niek Boutin, Thibaud S. Mangino, Massimo Ntalla, Ioanna Feofanova, Elena Surendran, Praveen Cook, James P. Karthikeyan, Savita Lahrouchi, Najim Liu, Chunyu Sepúlveda, Nuno Richardson, Tom G. Kraja, Aldi Amouyel, Philippe Farrall, Martin Poulter, Neil R. Laakso, Markku Zeggini, Eleftheria Sever, Peter Scott, Robert A. Langenberg, Claudia Wareham, Nicholas J. Conen, David Alexander Palmer, Colin Neil Attia, John Chasman, Daniel I. Ridker, Paul M. Melander, Olle Mook-Kanamori, Dennis Owen van der Harst, Pim Cucca, Francesco Schlessinger, David Hayward, Caroline Spector, Tim D. Marjo-Riitta, Jarvelin Hennig, Branwen J. Timpson, Nicholas J. Wei-Qi, Wei Smith, Joshua C. Xu, Yaomin Matheny, Michael E. Siew, Edward E. Lindgren, Cecilia Karl-Heinz, Herzig Dedoussis, George Denny, Joshua C. Psaty, Bruce M. Howson, Joanna M. M. Munroe, Patricia B. Newton-Cheh, Christopher Caulfield, Mark J. Elliott, Paul Gaziano, J. Michael Concato, John Wilson, Peter W.F. Tsao, Philip S. Velez Edwards, Digna R. Susztak, Katalin O’Donnell, Christopher J. Hung, Adriana M. Edwards, Todd L. Trans-ethnic association study of blood pressure determinants in over 750,000 individuals |
| title | Trans-ethnic association study of blood pressure determinants in over 750,000 individuals |
| title_full | Trans-ethnic association study of blood pressure determinants in over 750,000 individuals |
| title_fullStr | Trans-ethnic association study of blood pressure determinants in over 750,000 individuals |
| title_full_unstemmed | Trans-ethnic association study of blood pressure determinants in over 750,000 individuals |
| title_short | Trans-ethnic association study of blood pressure determinants in over 750,000 individuals |
| title_sort | trans-ethnic association study of blood pressure determinants in over 750,000 individuals |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365102/ https://www.ncbi.nlm.nih.gov/pubmed/30578418 http://dx.doi.org/10.1038/s41588-018-0303-9 |
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