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The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice
Schizophrenia (SCZ) is a devastating mental disorder with poorly defined underlying molecular mechanisms. The gut microbiome can modulate brain function and behaviors through the microbiota-gut-brain axis. Here, we found that unmedicated and medicated patients with SCZ had a decreased microbiome α-d...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365110/ https://www.ncbi.nlm.nih.gov/pubmed/30775438 http://dx.doi.org/10.1126/sciadv.aau8317 |
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author | Zheng, Peng Zeng, Benhua Liu, Meiling Chen, Jianjun Pan, Junxi Han, Yu Liu, Yiyun Cheng, Ke Zhou, Chanjuan Wang, Haiyang Zhou, Xinyu Gui, Siwen Perry, Seth W. Wong, Ma-Li Licinio, Julio Wei, Hong Xie, Peng |
author_facet | Zheng, Peng Zeng, Benhua Liu, Meiling Chen, Jianjun Pan, Junxi Han, Yu Liu, Yiyun Cheng, Ke Zhou, Chanjuan Wang, Haiyang Zhou, Xinyu Gui, Siwen Perry, Seth W. Wong, Ma-Li Licinio, Julio Wei, Hong Xie, Peng |
author_sort | Zheng, Peng |
collection | PubMed |
description | Schizophrenia (SCZ) is a devastating mental disorder with poorly defined underlying molecular mechanisms. The gut microbiome can modulate brain function and behaviors through the microbiota-gut-brain axis. Here, we found that unmedicated and medicated patients with SCZ had a decreased microbiome α-diversity index and marked disturbances of gut microbial composition versus healthy controls (HCs). Several unique bacterial taxa (e.g., Veillonellaceae and Lachnospiraceae) were associated with SCZ severity. A specific microbial panel (Aerococcaceae, Bifidobacteriaceae, Brucellaceae, Pasteurellaceae, and Rikenellaceae) enabled discriminating patients with SCZ from HCs with 0.769 area under the curve. Compared to HCs, germ-free mice receiving SCZ microbiome fecal transplants had lower glutamate and higher glutamine and GABA in the hippocampus and displayed SCZ-relevant behaviors similar to other mouse models of SCZ involving glutamatergic hypofunction. Together, our findings suggest that the SCZ microbiome itself can alter neurochemistry and neurologic function in ways that may be relevant to SCZ pathology. |
format | Online Article Text |
id | pubmed-6365110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63651102019-02-15 The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice Zheng, Peng Zeng, Benhua Liu, Meiling Chen, Jianjun Pan, Junxi Han, Yu Liu, Yiyun Cheng, Ke Zhou, Chanjuan Wang, Haiyang Zhou, Xinyu Gui, Siwen Perry, Seth W. Wong, Ma-Li Licinio, Julio Wei, Hong Xie, Peng Sci Adv Research Articles Schizophrenia (SCZ) is a devastating mental disorder with poorly defined underlying molecular mechanisms. The gut microbiome can modulate brain function and behaviors through the microbiota-gut-brain axis. Here, we found that unmedicated and medicated patients with SCZ had a decreased microbiome α-diversity index and marked disturbances of gut microbial composition versus healthy controls (HCs). Several unique bacterial taxa (e.g., Veillonellaceae and Lachnospiraceae) were associated with SCZ severity. A specific microbial panel (Aerococcaceae, Bifidobacteriaceae, Brucellaceae, Pasteurellaceae, and Rikenellaceae) enabled discriminating patients with SCZ from HCs with 0.769 area under the curve. Compared to HCs, germ-free mice receiving SCZ microbiome fecal transplants had lower glutamate and higher glutamine and GABA in the hippocampus and displayed SCZ-relevant behaviors similar to other mouse models of SCZ involving glutamatergic hypofunction. Together, our findings suggest that the SCZ microbiome itself can alter neurochemistry and neurologic function in ways that may be relevant to SCZ pathology. American Association for the Advancement of Science 2019-02-06 /pmc/articles/PMC6365110/ /pubmed/30775438 http://dx.doi.org/10.1126/sciadv.aau8317 Text en Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Zheng, Peng Zeng, Benhua Liu, Meiling Chen, Jianjun Pan, Junxi Han, Yu Liu, Yiyun Cheng, Ke Zhou, Chanjuan Wang, Haiyang Zhou, Xinyu Gui, Siwen Perry, Seth W. Wong, Ma-Li Licinio, Julio Wei, Hong Xie, Peng The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice |
title | The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice |
title_full | The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice |
title_fullStr | The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice |
title_full_unstemmed | The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice |
title_short | The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice |
title_sort | gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-gaba cycle and schizophrenia-relevant behaviors in mice |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365110/ https://www.ncbi.nlm.nih.gov/pubmed/30775438 http://dx.doi.org/10.1126/sciadv.aau8317 |
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