Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells

Breast cancer (BC) resistance to endocrine therapy results from constitutively active or aberrant estrogen receptor α (ERα) signaling, and ways to block ERα pathway in these tumors are sought after. We identified the H3K79 methyltransferase DOT1L as a novel cofactor of ERα in BC cell chromatin, wher...

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Detalles Bibliográficos
Autores principales: Nassa, Giovanni, Salvati, Annamaria, Tarallo, Roberta, Gigantino, Valerio, Alexandrova, Elena, Memoli, Domenico, Sellitto, Assunta, Rizzo, Francesca, Malanga, Donatella, Mirante, Teresa, Morelli, Eugenio, Nees, Matthias, Åkerfelt, Malin, Kangaspeska, Sara, Nyman, Tuula A., Milanesi, Luciano, Giurato, Giorgio, Weisz, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365116/
https://www.ncbi.nlm.nih.gov/pubmed/30775443
http://dx.doi.org/10.1126/sciadv.aav5590

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