NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages

Retinoic acid–inducible gene I (RIG-I), a pivotal cytosolic sensor, recognizes viral RNAs to initiate antiviral innate immunity. However, posttranslational regulation of RIG-I signaling is not well understood. We report here that nuclear Dbf2-related kinase 2 (NDR2) functions as a crucial positive r...

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Detalles Bibliográficos
Autores principales: Liu, Zhiyong, Wu, Cheng, Pan, Yueyun, Liu, Huan, Wang, Xiumei, Yang, Yuting, Gu, Meidi, Zhang, Yuanyuan, Wang, Xiaojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365120/
https://www.ncbi.nlm.nih.gov/pubmed/30775439
http://dx.doi.org/10.1126/sciadv.aav0163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365120/
https://www.ncbi.nlm.nih.gov/pubmed/30775439
http://dx.doi.org/10.1126/sciadv.aav0163

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