Cargando…

GLP-1 Receptor Agonist Exendin-4 Attenuates NR4A Orphan Nuclear Receptor NOR1 Expression in Vascular Smooth Muscle Cells

Aims: Recently, incretin therapy has attracted increasing attention because of its potential use in tissue-protective therapy. Neuron-derived orphan receptor 1 (NOR1) is a nuclear orphan receptor that regulates vascular smooth muscle cell (VSMC) proliferation. In the present study, we investigated t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takahashi, Hiroyuki, Nomiyama, Takashi, Terawaki, Yuichi, Kawanami, Takako, Hamaguchi, Yuriko, Tanaka, Tomoko, Tanabe, Makito, Bruemmer, Dennis, Yanase, Toshihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Japan Atherosclerosis Society 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365156/ https://www.ncbi.nlm.nih.gov/pubmed/29962378 http://dx.doi.org/10.5551/jat.43414

Ejemplares similares

Combined Treatment with Exendin-4 and Metformin Attenuates Prostate Cancer Growth
por: Tsutsumi, Yoko, et al.
Publicado: (2015)

Dipeptidyl peptidase-4 inhibitor linagliptin attenuates neointima formation after vascular injury
por: Terawaki, Yuichi, et al.
Publicado: (2014)

Combined treatment with DPP-4 inhibitor linagliptin and SGLT2 inhibitor empagliflozin attenuates neointima formation after vascular injury in diabetic mice
por: Takahashi, Hiroyuki, et al.
Publicado: (2019)

Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line
por: Fukuda, Takashi, et al.
Publicado: (2016)

Activation of overexpressed glucagon‐like peptide‐1 receptor attenuates prostate cancer growth by inhibiting cell cycle progression
por: Shigeoka, Toru, et al.
Publicado: (2020)

Pemafibrate, a PPAR alpha agonist, attenuates neointima formation after vascular injury in mice fed normal chow and a high-fat diet
por: Horikawa, Tsuyoshi, et al.
Publicado: (2020)

Prescription of oral hypoglycemic agents for patients with type 2 diabetes mellitus: A retrospective cohort study using a Japanese hospital database
por: Tanabe, Makito, et al.
Publicado: (2016)

Selective androgen receptor modulator, S42 has anabolic and anti-catabolic effects on cultured myotubes
por: Muta, Yoshimi, et al.
Publicado: (2019)

Impact of metabolic disorders on prostate cancer growth: Androgen and insulin resistance perspectives
por: Yanase, Tashihiko, et al.
Publicado: (2017)

Disruption of Beta-Cell Mitochondrial Networks by the Orphan Nuclear Receptor Nor1/Nr4a3
por: Close, Anne-Françoise, et al.
Publicado: (2020)

Deletion of the NR4A nuclear receptor NOR1 in hematopoietic stem cells reduces inflammation but not abdominal aortic aneurysm formation
por: Qing, Hua, et al.
Publicado: (2017)

Efficacy of dipeptidyl peptidase-4 inhibitor linagliptin in patients with type 2 diabetes undergoing hemodialysis
por: Terawaki, Yuichi, et al.
Publicado: (2015)

In Silico Adoption of an Orphan Nuclear Receptor NR4A1
por: Lanig, Harald, et al.
Publicado: (2015)

Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes
por: Zhang, Chenyang, et al.
Publicado: (2020)

Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology
por: Odagiu, Livia, et al.
Publicado: (2021)

GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor
por: Fusco, Joseph, et al.
Publicado: (2017)

Brain Imaging of the GLP-1 Receptor in Obesity Using (68)Ga-NODAGA-Exendin-4 PET
por: Deden, Laura N., et al.
Publicado: (2021)

Signaling Mechanism for Modulation by GLP-1 and Exendin-4 of GABA Receptors on Rat Retinal Ganglion Cells
por: Zhang, Tao, et al.
Publicado: (2022)

SUN-026 Selective Androgen Receptor Modulator S42 Has Anabolic and Anti-Catabolic Effects on Cultured Myotubes
por: Muta, Yoshimi, et al.
Publicado: (2019)

Reduced vascular events in type 2 diabetes by biguanide relative to sulfonylurea: study in a Japanese Hospital Database
por: Tanabe, Makito, et al.
Publicado: (2015)

Evaluation of an [(18)F]AlF-NOTA Analog of Exendin-4 for Imaging of GLP-1 Receptor in Insulinoma
por: Kiesewetter, Dale O., et al.
Publicado: (2012)

Piperlongumine is a ligand for the orphan nuclear receptor 4A1 (NR4A1)
por: Zhang, Lei, et al.
Publicado: (2023)

Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced β-cell function in non-diabetic subjects
por: Weyrich, Peter, et al.
Publicado: (2009)

Druggability Evaluation of the Neuron Derived Orphan Receptor (NOR‐1) Reveals Inverse NOR‐1 Agonists
por: Zaienne, Daniel, et al.
Publicado: (2022)

Flavone and Hydroxyflavones Are Ligands That Bind the Orphan Nuclear Receptor 4A1 (NR4A1)
por: Lee, Miok, et al.
Publicado: (2023)

The GLP-1 agonist, exendin-4, stimulates LH secretion in female sheep
por: Simpson, Elizabeth M, et al.
Publicado: (2023)

Type 2 diabetes-induced neuronal pathology in the piriform cortex of the rat is reversed by the GLP-1 receptor agonist exendin-4
por: Lietzau, Grazyna, et al.
Publicado: (2016)

Orphan nuclear receptor NR4A2 induces transcription of the immunomodulatory peptide hormone prolactin
por: McCoy, Joseph M, et al.
Publicado: (2015)

Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues
por: Herring, Jacob A., et al.
Publicado: (2019)

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4(+) T cells
por: Sekiya, Takashi, et al.
Publicado: (2011)

OR02-2 CX-4945 as a Potential Drug for Adrenocortical Carcinoma That Induces Multiple Exon-Skipping and Circular RNA of NR5A1
por: Tanaka, Tomoko, et al.
Publicado: (2019)

Nuclear Receptor 4a3 (Nr4a3) Regulates Murine Mast Cell Responses and Granule Content
por: Garcia-Faroldi, Gianni, et al.
Publicado: (2014)

Relevance of the NR4A sub-family of nuclear orphan receptors in trophoblastic BeWo cell differentiation
por: Malhotra, Sudha Saryu, et al.
Publicado: (2017)

Oncogenic Orphan Nuclear Receptor NR4A3 Interacts and Cooperates with MYB in Acinic Cell Carcinoma
por: Lee, David Y., et al.
Publicado: (2020)

Purification and bioactivity of exendin-4, a peptide analogue of GLP-1, expressed in Pichia pastoris
por: Zhou, Jin, et al.
Publicado: (2007)

Gut Peptide GLP-1 and Its Analogue, Exendin-4, Decrease Alcohol Intake and Reward
por: Shirazi, Rozita H., et al.
Publicado: (2013)

Synthesis, Optimization, and Biological Evaluation of Corrinated Conjugates of the GLP-1R Agonist Exendin-4
por: Tinsley, Ian C., et al.
Publicado: (2021)

(18)F-Labelled exendin to image GLP-1 receptor-expressing tissues: from niche to blockbuster?
por: Boerman, Otto C., et al.
Publicado: (2011)

Exendin-4 inhibits atrial arrhythmogenesis in a model of myocardial infarction-induced heart failure via the GLP-1 receptor signaling pathway
por: Chen, Jingjing, et al.
Publicado: (2020)

Exendin‐4, a GLP‐1 receptor agonist regulates retinal capillary tone and restores microvascular patency after ischaemia–reperfusion injury
por: Zhai, Ruyi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bgt1ck21f5hopsp4pqb3fd5300