LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma

Certain cancers, including gastrointestinal stromal tumor (GIST) and subsets of melanoma, are caused by somatic KIT mutations that result in KIT receptor tyrosine kinase constitutive activity, which drives proliferation. The treatment of KIT-mutant GIST has been revolutionized with the advent of KIT...

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Detalles Bibliográficos
Autores principales: Klug, Lillian R., Bannon, Amber E., Javidi-Sharifi, Nathalie, Town, Ajia, Fleming, William H., VanSlyke, Judy, Musil, Linda, Fletcher, Jonathan A., Tyner, Jeffrey W., Heinrich, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365197/
https://www.ncbi.nlm.nih.gov/pubmed/30242244
http://dx.doi.org/10.1038/s41388-018-0508-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365197/
https://www.ncbi.nlm.nih.gov/pubmed/30242244
http://dx.doi.org/10.1038/s41388-018-0508-5

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