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Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes
Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS. Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis. Activation of NF-κB attenuates HSPC numbers and function ex vivo.
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365382/ https://www.ncbi.nlm.nih.gov/pubmed/30315231 http://dx.doi.org/10.1038/s41375-018-0267-x |
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| author | Ping, Zhen Chen, Si Hermans, Sjoerd J. F. Kenswil, Keane J. G. Feyen, Jacqueline van Dijk, Claire Bindels, Eric M. J. Mylona, Athina M. Adisty, Niken M. Hoogenboezem, Remco M. Sanders, Mathijs A. Cremers, Eline M. P. Lindenbergh-Kortleve, Dicky J. Samsom, Janneke N. van de Loosdrecht, Arjan A. Raaijmakers, Marc H. G. P. |
| author_facet | Ping, Zhen Chen, Si Hermans, Sjoerd J. F. Kenswil, Keane J. G. Feyen, Jacqueline van Dijk, Claire Bindels, Eric M. J. Mylona, Athina M. Adisty, Niken M. Hoogenboezem, Remco M. Sanders, Mathijs A. Cremers, Eline M. P. Lindenbergh-Kortleve, Dicky J. Samsom, Janneke N. van de Loosdrecht, Arjan A. Raaijmakers, Marc H. G. P. |
| author_sort | Ping, Zhen |
| collection | PubMed |
| description | Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS. Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis. Activation of NF-κB attenuates HSPC numbers and function ex vivo. |
| format | Online Article Text |
| id | pubmed-6365382 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-63653822019-02-08 Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes Ping, Zhen Chen, Si Hermans, Sjoerd J. F. Kenswil, Keane J. G. Feyen, Jacqueline van Dijk, Claire Bindels, Eric M. J. Mylona, Athina M. Adisty, Niken M. Hoogenboezem, Remco M. Sanders, Mathijs A. Cremers, Eline M. P. Lindenbergh-Kortleve, Dicky J. Samsom, Janneke N. van de Loosdrecht, Arjan A. Raaijmakers, Marc H. G. P. Leukemia Brief Communication Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS. Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis. Activation of NF-κB attenuates HSPC numbers and function ex vivo. Nature Publishing Group UK 2018-10-12 2019 /pmc/articles/PMC6365382/ /pubmed/30315231 http://dx.doi.org/10.1038/s41375-018-0267-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Brief Communication Ping, Zhen Chen, Si Hermans, Sjoerd J. F. Kenswil, Keane J. G. Feyen, Jacqueline van Dijk, Claire Bindels, Eric M. J. Mylona, Athina M. Adisty, Niken M. Hoogenboezem, Remco M. Sanders, Mathijs A. Cremers, Eline M. P. Lindenbergh-Kortleve, Dicky J. Samsom, Janneke N. van de Loosdrecht, Arjan A. Raaijmakers, Marc H. G. P. Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes |
| title | Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes |
| title_full | Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes |
| title_fullStr | Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes |
| title_full_unstemmed | Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes |
| title_short | Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes |
| title_sort | activation of nf-κb driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes |
| topic | Brief Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365382/ https://www.ncbi.nlm.nih.gov/pubmed/30315231 http://dx.doi.org/10.1038/s41375-018-0267-x |
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