Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes

Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS. Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis. Activation of NF-κB attenuates HSPC numbers and function ex vivo.

Detalles Bibliográficos
Autores principales: Ping, Zhen, Chen, Si, Hermans, Sjoerd J. F., Kenswil, Keane J. G., Feyen, Jacqueline, van Dijk, Claire, Bindels, Eric M. J., Mylona, Athina M., Adisty, Niken M., Hoogenboezem, Remco M., Sanders, Mathijs A., Cremers, Eline M. P., Lindenbergh-Kortleve, Dicky J., Samsom, Janneke N., van de Loosdrecht, Arjan A., Raaijmakers, Marc H. G. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365382/
https://www.ncbi.nlm.nih.gov/pubmed/30315231
http://dx.doi.org/10.1038/s41375-018-0267-x

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