Responses in multiple myeloma should be assigned according to serum, not urine, free light chain measurements

The most recent update to the International Myeloma Working Group consensus criteria places a strong emphasis on the need for more sensitive haematological markers of response driven by the success of novel therapies. One such marker is serum free light chain (sFLC) analysis, which was first incorpo...

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Autores principales: Dejoie, Thomas, Corre, Jill, Caillon, Helene, Moreau, Philippe, Attal, Michel, Loiseau, Hervé Avet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365491/
https://www.ncbi.nlm.nih.gov/pubmed/30573778
http://dx.doi.org/10.1038/s41375-018-0339-y
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author Dejoie, Thomas
Corre, Jill
Caillon, Helene
Moreau, Philippe
Attal, Michel
Loiseau, Hervé Avet
author_facet Dejoie, Thomas
Corre, Jill
Caillon, Helene
Moreau, Philippe
Attal, Michel
Loiseau, Hervé Avet
author_sort Dejoie, Thomas
collection PubMed
description The most recent update to the International Myeloma Working Group consensus criteria places a strong emphasis on the need for more sensitive haematological markers of response driven by the success of novel therapies. One such marker is serum free light chain (sFLC) analysis, which was first incorporated into the definition of stringent complete response in 2006. However, over the past decade there has been some reluctance to extend the role of the sFLC assays to replace 24 h urine electrophoresis for monitoring multiple myeloma (MM). In this review, we lay out the evidence in favour of serum over urine for monoclonal FLC measurements and propose modified criteria for response assignment in myeloma.
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spelling pubmed-63654912019-02-08 Responses in multiple myeloma should be assigned according to serum, not urine, free light chain measurements Dejoie, Thomas Corre, Jill Caillon, Helene Moreau, Philippe Attal, Michel Loiseau, Hervé Avet Leukemia Review Article The most recent update to the International Myeloma Working Group consensus criteria places a strong emphasis on the need for more sensitive haematological markers of response driven by the success of novel therapies. One such marker is serum free light chain (sFLC) analysis, which was first incorporated into the definition of stringent complete response in 2006. However, over the past decade there has been some reluctance to extend the role of the sFLC assays to replace 24 h urine electrophoresis for monitoring multiple myeloma (MM). In this review, we lay out the evidence in favour of serum over urine for monoclonal FLC measurements and propose modified criteria for response assignment in myeloma. Nature Publishing Group UK 2018-12-20 2019 /pmc/articles/PMC6365491/ /pubmed/30573778 http://dx.doi.org/10.1038/s41375-018-0339-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Dejoie, Thomas
Corre, Jill
Caillon, Helene
Moreau, Philippe
Attal, Michel
Loiseau, Hervé Avet
Responses in multiple myeloma should be assigned according to serum, not urine, free light chain measurements
title Responses in multiple myeloma should be assigned according to serum, not urine, free light chain measurements
title_full Responses in multiple myeloma should be assigned according to serum, not urine, free light chain measurements
title_fullStr Responses in multiple myeloma should be assigned according to serum, not urine, free light chain measurements
title_full_unstemmed Responses in multiple myeloma should be assigned according to serum, not urine, free light chain measurements
title_short Responses in multiple myeloma should be assigned according to serum, not urine, free light chain measurements
title_sort responses in multiple myeloma should be assigned according to serum, not urine, free light chain measurements
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365491/
https://www.ncbi.nlm.nih.gov/pubmed/30573778
http://dx.doi.org/10.1038/s41375-018-0339-y
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