2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain

There is an urgent need to develop new drugs against tuberculosis. In particular, it is critical to target drug tolerant Mycobacterium tuberculosis (M. tuberculosis), responsible, in part, for the lengthy antibiotic regimen required for treatment. We previously postulated that the presence of in viv...

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Detalles Bibliográficos
Autores principales: Jeon, Albert Byungyun, Ackart, David F., Li, Wei, Jackson, Mary, Melander, Roberta J., Melander, Christian, Abramovitch, Robert B., Chicco, Adam J., Basaraba, Randall J., Obregón-Henao, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365497/
https://www.ncbi.nlm.nih.gov/pubmed/30728417
http://dx.doi.org/10.1038/s41598-018-38064-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365497/
https://www.ncbi.nlm.nih.gov/pubmed/30728417
http://dx.doi.org/10.1038/s41598-018-38064-7

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