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Traditional risk factors for essential hypertension: analysis of their specific combinations in the EPIC-Potsdam cohort
Appropriate interventions might improve the prevention of essential hypertension. This requires a comprehensive view of modifiable lifestyle factors (MLFs) distribution and effect. To determine how six MLFs (general adiposity, abdominal adiposity, alcohol consumption, smoking, diet, physical inactiv...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365562/ https://www.ncbi.nlm.nih.gov/pubmed/30728434 http://dx.doi.org/10.1038/s41598-019-38783-5 |
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author | Andriolo, Violetta Dietrich, Stefan Knüppel, Sven Bernigau, Wolfgang Boeing, Heiner |
author_facet | Andriolo, Violetta Dietrich, Stefan Knüppel, Sven Bernigau, Wolfgang Boeing, Heiner |
author_sort | Andriolo, Violetta |
collection | PubMed |
description | Appropriate interventions might improve the prevention of essential hypertension. This requires a comprehensive view of modifiable lifestyle factors (MLFs) distribution and effect. To determine how six MLFs (general adiposity, abdominal adiposity, alcohol consumption, smoking, diet, physical inactivity) for risk of hypertension are distributed and how their combinations affect the risk, a prospective study cohort of 11,923 healthy participants from the population-based European Prospective Investigation into Cancer and Nutrition (EPIC)–Potsdam Study was used. Of these, 1,635 developed hypertension during a mean follow-up of 10.3 years. Mutually exclusive combinations, clustering and interactions of MLFs were then investigated stratifying by sex, Hazard Ratios (HRs) and Population Attributable Risks (PARs%) were calculated. General adiposity alone was sufficient to increase the risk of hypertension (HR = 1.86, PAR% 3.36), and in this cohort it played a major role in enhancing the risk of hypertension, together with smoking and physical inactivity. MLFs had a different impact and a different modulation of risk in women and men, and they showed a remarkable tendency to occur in specific patterns with higher prevalence than expected. This indication can help to promote a holistic approach through multifactorial preventive strategies addressing more than a factor at a time. For prevention of hypertension addressing adiposity together with smoking, promoting at the same time physical activity should be the first choice. |
format | Online Article Text |
id | pubmed-6365562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63655622019-02-08 Traditional risk factors for essential hypertension: analysis of their specific combinations in the EPIC-Potsdam cohort Andriolo, Violetta Dietrich, Stefan Knüppel, Sven Bernigau, Wolfgang Boeing, Heiner Sci Rep Article Appropriate interventions might improve the prevention of essential hypertension. This requires a comprehensive view of modifiable lifestyle factors (MLFs) distribution and effect. To determine how six MLFs (general adiposity, abdominal adiposity, alcohol consumption, smoking, diet, physical inactivity) for risk of hypertension are distributed and how their combinations affect the risk, a prospective study cohort of 11,923 healthy participants from the population-based European Prospective Investigation into Cancer and Nutrition (EPIC)–Potsdam Study was used. Of these, 1,635 developed hypertension during a mean follow-up of 10.3 years. Mutually exclusive combinations, clustering and interactions of MLFs were then investigated stratifying by sex, Hazard Ratios (HRs) and Population Attributable Risks (PARs%) were calculated. General adiposity alone was sufficient to increase the risk of hypertension (HR = 1.86, PAR% 3.36), and in this cohort it played a major role in enhancing the risk of hypertension, together with smoking and physical inactivity. MLFs had a different impact and a different modulation of risk in women and men, and they showed a remarkable tendency to occur in specific patterns with higher prevalence than expected. This indication can help to promote a holistic approach through multifactorial preventive strategies addressing more than a factor at a time. For prevention of hypertension addressing adiposity together with smoking, promoting at the same time physical activity should be the first choice. Nature Publishing Group UK 2019-02-06 /pmc/articles/PMC6365562/ /pubmed/30728434 http://dx.doi.org/10.1038/s41598-019-38783-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Andriolo, Violetta Dietrich, Stefan Knüppel, Sven Bernigau, Wolfgang Boeing, Heiner Traditional risk factors for essential hypertension: analysis of their specific combinations in the EPIC-Potsdam cohort |
title | Traditional risk factors for essential hypertension: analysis of their specific combinations in the EPIC-Potsdam cohort |
title_full | Traditional risk factors for essential hypertension: analysis of their specific combinations in the EPIC-Potsdam cohort |
title_fullStr | Traditional risk factors for essential hypertension: analysis of their specific combinations in the EPIC-Potsdam cohort |
title_full_unstemmed | Traditional risk factors for essential hypertension: analysis of their specific combinations in the EPIC-Potsdam cohort |
title_short | Traditional risk factors for essential hypertension: analysis of their specific combinations in the EPIC-Potsdam cohort |
title_sort | traditional risk factors for essential hypertension: analysis of their specific combinations in the epic-potsdam cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365562/ https://www.ncbi.nlm.nih.gov/pubmed/30728434 http://dx.doi.org/10.1038/s41598-019-38783-5 |
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