Cargando…

Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels

Aldosterone is released from adrenal zona glomerulosa (ZG) cells and plays an important role in Na and K homoeostasis. Mutations in the human inwardly rectifying K channel CNJ type (KCNJ) 5 (KCNJ5) gene encoding the G-coupled inwardly rectifying K channel 4 (GIRK4) cause abnormal aldosterone secreti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hardege, Iris, Long, Lu, Al Maskari, Raya, Figg, Nicola, O’Shaughnessy, Kevin M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365593/ https://www.ncbi.nlm.nih.gov/pubmed/29222092 http://dx.doi.org/10.1042/CS20171285

Ejemplares similares

Functional characterization of common BCL11B gene desert variants suggests a lymphocyte-mediated association of BCL11B with aortic stiffness
por: Maskari, Raya Al, et al.
Publicado: (2018)

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia
por: Schumacher, Frances-Rose, et al.
Publicado: (2015)

Clinical Translationality of KCNJ5 Mutation in Aldosterone Producing Adenoma
por: Kitamoto, Takumi, et al.
Publicado: (2022)

Recurrence of Primary Aldosteronism After Surgery in Aldosterone-producing Adenoma With KCNJ5 Gene Mutation
por: Aiga, Ko, et al.
Publicado: (2023)

Primary aldosteronism caused by a pI157S somatic KCNJ5 mutation in a black adolescent female with aldosterone-producing adenoma
por: Gomez-Sanchez, Celso E., et al.
Publicado: (2022)

Cardiovascular and metabolic characters of KCNJ5 somatic mutations in primary aldosteronism
por: Chang, Yi-Yao, et al.
Publicado: (2023)

Genetic Variations in the KCNJ5 Gene in Primary Aldosteronism Patients from Xinjiang, China
por: Li, Nan-Fang, et al.
Publicado: (2013)

Prevalence of Somatic KCNJ5 Mutations in Thai Patients With Aldosterone-Producing Adrenal Adenomas
por: Warachit, Wasita, et al.
Publicado: (2018)

The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness
por: Yasmin, et al.
Publicado: (2018)

A Novel Case of Somatic KCNJ5 Mutation in Pediatric-Onset Aldosterone-Producing Adenoma
por: Uchida, Noboru, et al.
Publicado: (2017)

LBODP025 A Novel Drug Discovery For Primary Aldosteronism Targeting Aldosterone Synthase (cyp11b2) And Kcnj5 Mutant
por: Otsubo, Yuri, et al.
Publicado: (2022)

SAT-555 Can Histology Predict the Presence of KCNJ5 Somatic Mutation in Aldosterone-Producing Adenomas?
por: Yamazaki, Yuto, et al.
Publicado: (2020)

KCNJ5 Somatic Mutations in Aldosterone-Producing Adenoma Are Associated with a Greater Recovery of Arterial Stiffness
por: Chang, Yi-Yao, et al.
Publicado: (2021)

NP-59 Adrenal Scintigraphy as an Imaging Biomarker to Predict KCNJ5 Mutation in Primary Aldosteronism Patients
por: Lu, Ching-Chu, et al.
Publicado: (2021)

Arterial stiffness and blood pressure improvement in aldosterone-producing adenoma harboring KCNJ5 mutations after adrenalectomy
por: Chang, Chia-Hui, et al.
Publicado: (2017)

Prevalence and Histopathological Characteristics of KCNJ5 Mutant Aldosterone-Producing Adenomas in a Multi-Ethnic Malaysian Cohort
por: Mohideen, Syahirah Kaja, et al.
Publicado: (2019)

Pathophysiological and Pharmacological Characteristics of KCNJ5 157-159delITE Somatic Mutation in Aldosterone-Producing Adenomas
por: Peng, Kang-Yung, et al.
Publicado: (2021)

Identifying KCNJ5 Mutation in Aldosterone-Producing Adenoma Patients With Baseline Characteristics Using Machine Learning Technology
por: Chen, Li-Chin, et al.
Publicado: (2023)

FRI125 Recurrence Of Primary Aldosteronism Long-Term After Adrenalectomy For Aldosterone-Producing Adenoma With KCNJ5 Gene Mutation: A Two-Cases Report
por: Aiga, Ko, et al.
Publicado: (2023)

Actomyosin pulsing rescues embryonic tissue folding from disruption by myosin fluctuations
por: Zhu, Hongkang, et al.
Publicado: (2023)

KCNJ5 Somatic Mutation Is Associated With Higher Aortic Wall Thickness and Less Calcification in Patients With Aldosterone-Producing Adenoma
por: Lee, Bo-Ching, et al.
Publicado: (2022)

A novel mutation KCNJ11 R136C caused KCNJ11-MODY
por: Chen, Yaning, et al.
Publicado: (2021)

Effect of germ cell depletion on levels of specific mRNA transcripts in mouse Sertoli cells and Leydig cells
por: J O'Shaughnessy, P, et al.
Publicado: (2008)

Effects of FSH on testicular mRNA transcript levels in the hypogonadal mouse
por: Abel, M H, et al.
Publicado: (2009)

Comprehensive Re-Sequencing of Adrenal Aldosterone Producing Lesions Reveal Three Somatic Mutations near the KCNJ5 Potassium Channel Selectivity Filter
por: Åkerström, Tobias, et al.
Publicado: (2012)

Exploration of KCNJ5 Somatic Mutation and CYP11B1/CYP11B2 Staining in Multiple Nodules in Primary Aldosteronism
por: Xie, Jing, et al.
Publicado: (2022)

Different cell compositions and a novel somatic KCNJ5 variant found in a patient with bilateral adrenocortical adenomas secreting aldosterone and cortisol
por: Zhao, Liling, et al.
Publicado: (2023)

ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3(Δ403‐459) mutation
por: Murthy, Meena, et al.
Publicado: (2016)

The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester
por: Johnston, Zoe C., et al.
Publicado: (2018)

Ablation of Kcnj10 expression in retinal explants revealed pivotal roles for Kcnj10 in the proliferation and development of Müller glia
por: Arai, Eisuke, et al.
Publicado: (2015)

Aldosterone Disrupts the Intercellular Flow of Glucose in Cardiac Muscle
por: De Mello, Walmor C.
Publicado: (2015)

A clinical trial to evaluate the effect of statin use on lowering aldosterone levels
por: Hornik, Ezra S., et al.
Publicado: (2020)

The truth about economizing for college: shrinking the college tab
por: O'Shaughnessy, Lynn, et al.
Publicado: (2011)

Dissecting complex traits: recent advances in hypertension genomics
por: O'Shaughnessy, Kevin M
Publicado: (2009)

Relevance of KCNJ5 in Pathologies of Heart Disease
por: Meyer, Karisa M., et al.
Publicado: (2023)

Genetic Markers Regulating Blood Pressure in Extreme Discordant Sib Pairs
por: Yasmin, et al.
Publicado: (2023)

The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis
por: Yin, Wenguang, et al.
Publicado: (2018)

KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus
por: Haghvirdizadeh, Polin, et al.
Publicado: (2015)

Psychiatric morbidity in children with KCNJ11 neonatal diabetes
por: Bowman, P., et al.
Publicado: (2016)

Retinal Development and Pathophysiology in Kcnj13 Knockout Mice
por: Jiao, Xiaodong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hp3nnkjmeoslap1r7t2oqf3irm