MIB1 mutations reduce Notch signaling activation and contribute to congenital heart disease

Congenital heart disease (CHD) is one of the most common birth defects in humans, but its genetic etiology remains largely unknown despite decades of research. The Notch signaling pathway plays critical roles in embryonic cardiogenesis. Mind bomb 1 (Mib1) is a vital protein that activates the Notch...

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Detalles Bibliográficos
Autores principales: Li, Binbin, Yu, Liwei, Liu, Dong, Yang, Xueyan, Zheng, Yufang, Gui, Yonghao, Wang, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365626/
https://www.ncbi.nlm.nih.gov/pubmed/30322850
http://dx.doi.org/10.1042/CS20180732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365626/
https://www.ncbi.nlm.nih.gov/pubmed/30322850
http://dx.doi.org/10.1042/CS20180732

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