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Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner
Parent-of-origin effects, whereby specific phenotypes are differentially inherited paternally or maternally, provide useful clues to better understand transgenerational effect transmission. Ancestral diet influences offspring phenotypes, including body composition and fitness. However, the specific...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365861/ https://www.ncbi.nlm.nih.gov/pubmed/30966955 http://dx.doi.org/10.1098/rstb.2018.0181 |
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author | Emborski, Carmen Mikheyev, Alexander S. |
author_facet | Emborski, Carmen Mikheyev, Alexander S. |
author_sort | Emborski, Carmen |
collection | PubMed |
description | Parent-of-origin effects, whereby specific phenotypes are differentially inherited paternally or maternally, provide useful clues to better understand transgenerational effect transmission. Ancestral diet influences offspring phenotypes, including body composition and fitness. However, the specific role that mothers and fathers play in the transmission of altered phenotypes to male and female offspring remains unclear. We investigated the influence of the parent-of-origin's diet on adult progeny phenotypes and reproductive output for three generations in fruit flies (Drosophila melanogaster). Males and females reared on a control diet were exposed to the control diet or one of two altered (no- or high-) sugar treatment diets for a single generation. Flies from one of the two altered diet treatments were then mated to control flies in a full-factorial design to produce F(1) offspring and kept on control media for each following generation. We found parent-of-origin (triglyceride) and non-parent-of-origin (sugar) body composition effects, which were transgenerational and sex-specific. Additionally, we observed a negative correlation between intergenerational maternal reproductive output and triglyceride levels, suggesting that ancestral diet may affect fitness. This work demonstrates that ancestral diet can transmit altered phenotypes in a parent-of-origin and sex-specific manner and highlights that mechanisms regulating such transmission have been greatly overlooked. This article is part of the theme issue ‘The role of plasticity in phenotypic adaptation to rapid environmental change’. |
format | Online Article Text |
id | pubmed-6365861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-63658612019-02-20 Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner Emborski, Carmen Mikheyev, Alexander S. Philos Trans R Soc Lond B Biol Sci Articles Parent-of-origin effects, whereby specific phenotypes are differentially inherited paternally or maternally, provide useful clues to better understand transgenerational effect transmission. Ancestral diet influences offspring phenotypes, including body composition and fitness. However, the specific role that mothers and fathers play in the transmission of altered phenotypes to male and female offspring remains unclear. We investigated the influence of the parent-of-origin's diet on adult progeny phenotypes and reproductive output for three generations in fruit flies (Drosophila melanogaster). Males and females reared on a control diet were exposed to the control diet or one of two altered (no- or high-) sugar treatment diets for a single generation. Flies from one of the two altered diet treatments were then mated to control flies in a full-factorial design to produce F(1) offspring and kept on control media for each following generation. We found parent-of-origin (triglyceride) and non-parent-of-origin (sugar) body composition effects, which were transgenerational and sex-specific. Additionally, we observed a negative correlation between intergenerational maternal reproductive output and triglyceride levels, suggesting that ancestral diet may affect fitness. This work demonstrates that ancestral diet can transmit altered phenotypes in a parent-of-origin and sex-specific manner and highlights that mechanisms regulating such transmission have been greatly overlooked. This article is part of the theme issue ‘The role of plasticity in phenotypic adaptation to rapid environmental change’. The Royal Society 2019-03-18 2019-01-28 /pmc/articles/PMC6365861/ /pubmed/30966955 http://dx.doi.org/10.1098/rstb.2018.0181 Text en © 2019 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Articles Emborski, Carmen Mikheyev, Alexander S. Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner |
title | Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner |
title_full | Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner |
title_fullStr | Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner |
title_full_unstemmed | Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner |
title_short | Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner |
title_sort | ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365861/ https://www.ncbi.nlm.nih.gov/pubmed/30966955 http://dx.doi.org/10.1098/rstb.2018.0181 |
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