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Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner

Parent-of-origin effects, whereby specific phenotypes are differentially inherited paternally or maternally, provide useful clues to better understand transgenerational effect transmission. Ancestral diet influences offspring phenotypes, including body composition and fitness. However, the specific...

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Detalles Bibliográficos
Autores principales: Emborski, Carmen, Mikheyev, Alexander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365861/
https://www.ncbi.nlm.nih.gov/pubmed/30966955
http://dx.doi.org/10.1098/rstb.2018.0181
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author Emborski, Carmen
Mikheyev, Alexander S.
author_facet Emborski, Carmen
Mikheyev, Alexander S.
author_sort Emborski, Carmen
collection PubMed
description Parent-of-origin effects, whereby specific phenotypes are differentially inherited paternally or maternally, provide useful clues to better understand transgenerational effect transmission. Ancestral diet influences offspring phenotypes, including body composition and fitness. However, the specific role that mothers and fathers play in the transmission of altered phenotypes to male and female offspring remains unclear. We investigated the influence of the parent-of-origin's diet on adult progeny phenotypes and reproductive output for three generations in fruit flies (Drosophila melanogaster). Males and females reared on a control diet were exposed to the control diet or one of two altered (no- or high-) sugar treatment diets for a single generation. Flies from one of the two altered diet treatments were then mated to control flies in a full-factorial design to produce F(1) offspring and kept on control media for each following generation. We found parent-of-origin (triglyceride) and non-parent-of-origin (sugar) body composition effects, which were transgenerational and sex-specific. Additionally, we observed a negative correlation between intergenerational maternal reproductive output and triglyceride levels, suggesting that ancestral diet may affect fitness. This work demonstrates that ancestral diet can transmit altered phenotypes in a parent-of-origin and sex-specific manner and highlights that mechanisms regulating such transmission have been greatly overlooked. This article is part of the theme issue ‘The role of plasticity in phenotypic adaptation to rapid environmental change’.
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spelling pubmed-63658612019-02-20 Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner Emborski, Carmen Mikheyev, Alexander S. Philos Trans R Soc Lond B Biol Sci Articles Parent-of-origin effects, whereby specific phenotypes are differentially inherited paternally or maternally, provide useful clues to better understand transgenerational effect transmission. Ancestral diet influences offspring phenotypes, including body composition and fitness. However, the specific role that mothers and fathers play in the transmission of altered phenotypes to male and female offspring remains unclear. We investigated the influence of the parent-of-origin's diet on adult progeny phenotypes and reproductive output for three generations in fruit flies (Drosophila melanogaster). Males and females reared on a control diet were exposed to the control diet or one of two altered (no- or high-) sugar treatment diets for a single generation. Flies from one of the two altered diet treatments were then mated to control flies in a full-factorial design to produce F(1) offspring and kept on control media for each following generation. We found parent-of-origin (triglyceride) and non-parent-of-origin (sugar) body composition effects, which were transgenerational and sex-specific. Additionally, we observed a negative correlation between intergenerational maternal reproductive output and triglyceride levels, suggesting that ancestral diet may affect fitness. This work demonstrates that ancestral diet can transmit altered phenotypes in a parent-of-origin and sex-specific manner and highlights that mechanisms regulating such transmission have been greatly overlooked. This article is part of the theme issue ‘The role of plasticity in phenotypic adaptation to rapid environmental change’. The Royal Society 2019-03-18 2019-01-28 /pmc/articles/PMC6365861/ /pubmed/30966955 http://dx.doi.org/10.1098/rstb.2018.0181 Text en © 2019 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Articles
Emborski, Carmen
Mikheyev, Alexander S.
Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner
title Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner
title_full Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner
title_fullStr Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner
title_full_unstemmed Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner
title_short Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner
title_sort ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365861/
https://www.ncbi.nlm.nih.gov/pubmed/30966955
http://dx.doi.org/10.1098/rstb.2018.0181
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