Statins and Histone Deacetylase Inhibitors Affect Lamin A/C – Histone Deacetylase 2 Interaction in Human Cells

We recently identified lamin A/C as a docking molecule for human histone deacetylase 2 (HDAC2) and showed involvement of HDAC2-lamin A/C complexes in the DNA damage response. We further showed that lamin A/C-HDAC2 interaction is altered in Hutchinson-Gilford Progeria syndrome and other progeroid lam...

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Detalles Bibliográficos
Autores principales: Mattioli, Elisabetta, Andrenacci, Davide, Mai, Antonello, Valente, Sergio, Robijns, Joke, De Vos, Winnok H., Capanni, Cristina, Lattanzi, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365888/
https://www.ncbi.nlm.nih.gov/pubmed/30766871
http://dx.doi.org/10.3389/fcell.2019.00006

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