Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues

[Image: see text] APOBEC3 enzymes form part of the innate immune system by deaminating cytosine to uracil in single-stranded DNA (ssDNA) and thereby preventing the spread of pathogenic genetic information. However, APOBEC mutagenesis is also exploited by viruses and cancer cells to increase rates of...

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Detalles Bibliográficos
Autores principales: Kvach, Maksim V., Barzak, Fareeda M., Harjes, Stefan, Schares, Henry A. M., Jameson, Geoffrey B., Ayoub, Alex M., Moorthy, Ramkumar, Aihara, Hideki, Harris, Reuben S., Filichev, Vyacheslav V., Harki, Daniel A., Harjes, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365909/
https://www.ncbi.nlm.nih.gov/pubmed/30418757
http://dx.doi.org/10.1021/acs.biochem.8b00858

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