Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity

BACKGROUND: Tumor orchestrated metabolic changes in the microenvironment limit generation of anti-tumor immune responses. Availability of arginine, a semi-essential amino acid, is critical for lymphocyte proliferation and function. Levels of arginine are regulated by the enzymes arginase 1,2 and nit...

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Detalles Bibliográficos
Autores principales: Miret, Juan J., Kirschmeier, Paul, Koyama, Shohei, Zhu, Mingrui, Li, Yvonne Y., Naito, Yujiro, Wu, Min, Malladi, Venkat S., Huang, Wei, Walker, William, Palakurthi, Sangeetha, Dranoff, Glenn, Hammerman, Peter S., Pecot, Chad V., Wong, Kwok-Kin, Akbay, Esra A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366094/
https://www.ncbi.nlm.nih.gov/pubmed/30728077
http://dx.doi.org/10.1186/s40425-019-0504-5

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