Successful treatment of a Streptococcus pneumoniae-associated haemolytic uraemic syndrome by eculizumab

Haemolytic uraemic syndrome (HUS) is a rare complication of invasive infection by Streptococcus pneumoniae (SP-HUS), especially in adults. Here we report an unusual case of a 53-year-old man presenting SP-HUS with severe multivisceral involvement. After failure of supportive care and plasma exchange...

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Autores principales: Jeantet, Guillaume, Pernin, Vincent, Brunot, Vincent, Roccabianca, Arnaud, Macombe, Anouk, Szwarc, Ilan, Klouche, Kada, Loirat, Chantal, Mourad, Georges, Frémeaux-Bacchi, Véronique, Le Quintrec, Moglie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Infection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366139/
https://www.ncbi.nlm.nih.gov/pubmed/30746136
http://dx.doi.org/10.1093/ckj/sfy019
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author Jeantet, Guillaume
Pernin, Vincent
Brunot, Vincent
Roccabianca, Arnaud
Macombe, Anouk
Szwarc, Ilan
Klouche, Kada
Loirat, Chantal
Mourad, Georges
Frémeaux-Bacchi, Véronique
Le Quintrec, Moglie
author_facet Jeantet, Guillaume
Pernin, Vincent
Brunot, Vincent
Roccabianca, Arnaud
Macombe, Anouk
Szwarc, Ilan
Klouche, Kada
Loirat, Chantal
Mourad, Georges
Frémeaux-Bacchi, Véronique
Le Quintrec, Moglie
author_sort Jeantet, Guillaume
collection PubMed
description Haemolytic uraemic syndrome (HUS) is a rare complication of invasive infection by Streptococcus pneumoniae (SP-HUS), especially in adults. Here we report an unusual case of a 53-year-old man presenting SP-HUS with severe multivisceral involvement. After failure of supportive care and plasma exchanges, eculizumab (anti-C5 antibody) resulted in a favourable outcome.
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spelling pubmed-63661392019-02-11 Successful treatment of a Streptococcus pneumoniae-associated haemolytic uraemic syndrome by eculizumab Jeantet, Guillaume Pernin, Vincent Brunot, Vincent Roccabianca, Arnaud Macombe, Anouk Szwarc, Ilan Klouche, Kada Loirat, Chantal Mourad, Georges Frémeaux-Bacchi, Véronique Le Quintrec, Moglie Clin Kidney J Infection Haemolytic uraemic syndrome (HUS) is a rare complication of invasive infection by Streptococcus pneumoniae (SP-HUS), especially in adults. Here we report an unusual case of a 53-year-old man presenting SP-HUS with severe multivisceral involvement. After failure of supportive care and plasma exchanges, eculizumab (anti-C5 antibody) resulted in a favourable outcome. Oxford University Press 2018-03-20 /pmc/articles/PMC6366139/ /pubmed/30746136 http://dx.doi.org/10.1093/ckj/sfy019 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Infection
Jeantet, Guillaume
Pernin, Vincent
Brunot, Vincent
Roccabianca, Arnaud
Macombe, Anouk
Szwarc, Ilan
Klouche, Kada
Loirat, Chantal
Mourad, Georges
Frémeaux-Bacchi, Véronique
Le Quintrec, Moglie
Successful treatment of a Streptococcus pneumoniae-associated haemolytic uraemic syndrome by eculizumab
title Successful treatment of a Streptococcus pneumoniae-associated haemolytic uraemic syndrome by eculizumab
title_full Successful treatment of a Streptococcus pneumoniae-associated haemolytic uraemic syndrome by eculizumab
title_fullStr Successful treatment of a Streptococcus pneumoniae-associated haemolytic uraemic syndrome by eculizumab
title_full_unstemmed Successful treatment of a Streptococcus pneumoniae-associated haemolytic uraemic syndrome by eculizumab
title_short Successful treatment of a Streptococcus pneumoniae-associated haemolytic uraemic syndrome by eculizumab
title_sort successful treatment of a streptococcus pneumoniae-associated haemolytic uraemic syndrome by eculizumab
topic Infection
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366139/
https://www.ncbi.nlm.nih.gov/pubmed/30746136
http://dx.doi.org/10.1093/ckj/sfy019
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