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Myosin Heavy Chain 9: Oncogene or Tumor Suppressor Gene?
MYH9 was first discovered due to thrombocytopenia caused by MYH9 mutation-related abnormalities. In recent years, researchers have increasingly found that MYH9 plays an important role in cancer as a cytokine involved in cytoskeletal reorganization, cellular pseudopodia formation, and migration. MYH9...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366299/ https://www.ncbi.nlm.nih.gov/pubmed/30739906 http://dx.doi.org/10.12659/MSM.912320 |
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author | Wang, Yunmei Liu, Shuguang Zhang, Yanjun Yang, Jin |
author_facet | Wang, Yunmei Liu, Shuguang Zhang, Yanjun Yang, Jin |
author_sort | Wang, Yunmei |
collection | PubMed |
description | MYH9 was first discovered due to thrombocytopenia caused by MYH9 mutation-related abnormalities. In recent years, researchers have increasingly found that MYH9 plays an important role in cancer as a cytokine involved in cytoskeletal reorganization, cellular pseudopodia formation, and migration. MYH9 is closely related to the progress and poor prognosis of most solid tumors, and it is now accepted that MYH9 is a suppressor gene and plays an important role on the re-Rho pathway. Recent research has been limited to the study of tissues. However, it would be more direct and informative to be able to use hematology to assess tumor prognosis and changes in MYH9 levels and NMMHC-IIA. This article summarizes recent research on MYH9 and provides a reference for future clinical research. |
format | Online Article Text |
id | pubmed-6366299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63662992019-02-15 Myosin Heavy Chain 9: Oncogene or Tumor Suppressor Gene? Wang, Yunmei Liu, Shuguang Zhang, Yanjun Yang, Jin Med Sci Monit Review Articles MYH9 was first discovered due to thrombocytopenia caused by MYH9 mutation-related abnormalities. In recent years, researchers have increasingly found that MYH9 plays an important role in cancer as a cytokine involved in cytoskeletal reorganization, cellular pseudopodia formation, and migration. MYH9 is closely related to the progress and poor prognosis of most solid tumors, and it is now accepted that MYH9 is a suppressor gene and plays an important role on the re-Rho pathway. Recent research has been limited to the study of tissues. However, it would be more direct and informative to be able to use hematology to assess tumor prognosis and changes in MYH9 levels and NMMHC-IIA. This article summarizes recent research on MYH9 and provides a reference for future clinical research. International Scientific Literature, Inc. 2019-01-31 /pmc/articles/PMC6366299/ /pubmed/30739906 http://dx.doi.org/10.12659/MSM.912320 Text en © Med Sci Monit, 2019 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Review Articles Wang, Yunmei Liu, Shuguang Zhang, Yanjun Yang, Jin Myosin Heavy Chain 9: Oncogene or Tumor Suppressor Gene? |
title | Myosin Heavy Chain 9: Oncogene or Tumor Suppressor Gene? |
title_full | Myosin Heavy Chain 9: Oncogene or Tumor Suppressor Gene? |
title_fullStr | Myosin Heavy Chain 9: Oncogene or Tumor Suppressor Gene? |
title_full_unstemmed | Myosin Heavy Chain 9: Oncogene or Tumor Suppressor Gene? |
title_short | Myosin Heavy Chain 9: Oncogene or Tumor Suppressor Gene? |
title_sort | myosin heavy chain 9: oncogene or tumor suppressor gene? |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366299/ https://www.ncbi.nlm.nih.gov/pubmed/30739906 http://dx.doi.org/10.12659/MSM.912320 |
work_keys_str_mv | AT wangyunmei myosinheavychain9oncogeneortumorsuppressorgene AT liushuguang myosinheavychain9oncogeneortumorsuppressorgene AT zhangyanjun myosinheavychain9oncogeneortumorsuppressorgene AT yangjin myosinheavychain9oncogeneortumorsuppressorgene |