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Enantioselective Synthesis of Pharmaceutically Active γ-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions

[Image: see text] Chiral γ-aminobutyric acid (GABA) analogues represent abundantly prescribed drugs, which are broadly applied as anticonvulsants, as antidepressants, and for the treatment of neuropathic pain. Here we report a one-pot two-step biocatalytic cascade route for synthesis of the pharmace...

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Detalles Bibliográficos
Autores principales:	Biewenga, Lieuwe, Saravanan, Thangavelu, Kunzendorf, Andreas, van der Meer, Jan-Ytzen, Pijning, Tjaard, Tepper, Pieter G., van Merkerk, Ronald, Charnock, Simon J., Thunnissen, Andy-Mark W. H., Poelarends, Gerrit J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366683/ https://www.ncbi.nlm.nih.gov/pubmed/30740262 http://dx.doi.org/10.1021/acscatal.8b04299

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