Poor overall survival in hyperhaploid multiple myeloma is defined by double-hit bi-allelic inactivation of TP53

Hyperhaploid multiple myeloma is a rare numerical aberration group defined by a range of 24-34 chromosomes, which is associated with a poor prognosis with a 5-year survival rate of 23%. Hyperhaploid patient samples (n=8) were sequenced and copy number and mutations identified. Samples had a median o...

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Detalles Bibliográficos
Autores principales: Ashby, Cody, Tytarenko, Ruslana G., Wang, Yan, Weinhold, Niels, Johnson, Sarah K., Bauer, Michael, Wardell, Christopher P., Schinke, Carolina, Thanendrarajan, Sharmilan, Zangari, Mauricio, van Rhee, Frits, Davies, Faith E., Sawyer, Jeffrey R., Morgan, Gareth J., Walker, Brian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366829/
https://www.ncbi.nlm.nih.gov/pubmed/30774775
http://dx.doi.org/10.18632/oncotarget.26589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366829/
https://www.ncbi.nlm.nih.gov/pubmed/30774775
http://dx.doi.org/10.18632/oncotarget.26589

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