APRIL signaling via TACI mediates immunosuppression by T regulatory cells in multiple myeloma: therapeutic implications

We here investigate how APRIL impacts immune regulatory T cells and directly contributes to the immunosuppressive multiple myeloma (MM) bone marrow (BM) microenvironment. First, APRIL receptor TACI expression is significantly higher in regulatory T cells (Tregs) than conventional T cells (Tcons) fro...

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Detalles Bibliográficos
Autores principales: Tai, Yu-Tzu, Lin, Liang, Xing, Lijie, Cho, Shih-Feng, Yu, Tengteng, Acharya, Chirag, Wen, Kenneth, Hsieh, Phillip A, Dulos, John, van Elsas, Andrea, Munshi, Nikhil, Richardson, Paul, Anderson, Kenneth C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367000/
https://www.ncbi.nlm.nih.gov/pubmed/30135465
http://dx.doi.org/10.1038/s41375-018-0242-6

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