Successful Cord Blood Transplantation in a Werner Syndrome Patient with High-risk Myelodysplastic Syndrome

Werner syndrome (WS) confers a high risk of the development of neoplasias, including hematological malignancies, and curative treatment for these malignancies is difficult to achieve. A 44-year-old man with myelodysplastic syndrome was admitted to our hospital. He was diagnosed with mutation-proven...

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Autores principales: Hayashi, Kiyohito, Tasaka, Taizo, Kondo, Toshinori, Ishikawa, Yuichi, Goto, Makoto, Matsuhashi, Yoshiko, Sadahira, Yoshito, Sugihara, Takashi, Wada, Hideho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367075/
https://www.ncbi.nlm.nih.gov/pubmed/30146558
http://dx.doi.org/10.2169/internalmedicine.0317-17
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author Hayashi, Kiyohito
Tasaka, Taizo
Kondo, Toshinori
Ishikawa, Yuichi
Goto, Makoto
Matsuhashi, Yoshiko
Sadahira, Yoshito
Sugihara, Takashi
Wada, Hideho
author_facet Hayashi, Kiyohito
Tasaka, Taizo
Kondo, Toshinori
Ishikawa, Yuichi
Goto, Makoto
Matsuhashi, Yoshiko
Sadahira, Yoshito
Sugihara, Takashi
Wada, Hideho
author_sort Hayashi, Kiyohito
collection PubMed
description Werner syndrome (WS) confers a high risk of the development of neoplasias, including hematological malignancies, and curative treatment for these malignancies is difficult to achieve. A 44-year-old man with myelodysplastic syndrome was admitted to our hospital. He was diagnosed with mutation-proven WS. He underwent cord blood transplantation (CBT) following fludarabine, busulfan, and melphalan administration. A chimerism analysis of his marrow blood on day 62 showed a donor pattern ＞95%, which confirmed engraftment. The patient lived for 15 months while maintaining remission of MDS without treatment-related toxicity. Our case shows that CBT can be a treatment modality for WS patients with hematological malignancies.
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spelling pubmed-63670752019-02-08 Successful Cord Blood Transplantation in a Werner Syndrome Patient with High-risk Myelodysplastic Syndrome Hayashi, Kiyohito Tasaka, Taizo Kondo, Toshinori Ishikawa, Yuichi Goto, Makoto Matsuhashi, Yoshiko Sadahira, Yoshito Sugihara, Takashi Wada, Hideho Intern Med Case Report Werner syndrome (WS) confers a high risk of the development of neoplasias, including hematological malignancies, and curative treatment for these malignancies is difficult to achieve. A 44-year-old man with myelodysplastic syndrome was admitted to our hospital. He was diagnosed with mutation-proven WS. He underwent cord blood transplantation (CBT) following fludarabine, busulfan, and melphalan administration. A chimerism analysis of his marrow blood on day 62 showed a donor pattern ＞95%, which confirmed engraftment. The patient lived for 15 months while maintaining remission of MDS without treatment-related toxicity. Our case shows that CBT can be a treatment modality for WS patients with hematological malignancies. The Japanese Society of Internal Medicine 2018-08-24 2019-01-01 /pmc/articles/PMC6367075/ /pubmed/30146558 http://dx.doi.org/10.2169/internalmedicine.0317-17 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hayashi, Kiyohito
Tasaka, Taizo
Kondo, Toshinori
Ishikawa, Yuichi
Goto, Makoto
Matsuhashi, Yoshiko
Sadahira, Yoshito
Sugihara, Takashi
Wada, Hideho
Successful Cord Blood Transplantation in a Werner Syndrome Patient with High-risk Myelodysplastic Syndrome
title Successful Cord Blood Transplantation in a Werner Syndrome Patient with High-risk Myelodysplastic Syndrome
title_full Successful Cord Blood Transplantation in a Werner Syndrome Patient with High-risk Myelodysplastic Syndrome
title_fullStr Successful Cord Blood Transplantation in a Werner Syndrome Patient with High-risk Myelodysplastic Syndrome
title_full_unstemmed Successful Cord Blood Transplantation in a Werner Syndrome Patient with High-risk Myelodysplastic Syndrome
title_short Successful Cord Blood Transplantation in a Werner Syndrome Patient with High-risk Myelodysplastic Syndrome
title_sort successful cord blood transplantation in a werner syndrome patient with high-risk myelodysplastic syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367075/
https://www.ncbi.nlm.nih.gov/pubmed/30146558
http://dx.doi.org/10.2169/internalmedicine.0317-17
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