Intravenous Cyclophosphamide for Gastric Antral Vascular Ectasia Associated with Systemic Sclerosis Refractory to Endoscopic Treatment: A Case Report and Review of the Pertinent Literature

Gastric antral vascular ectasia (GAVE) is a rare cause of chronic gastric hemorrhaging and iron deficiency anemia and is characterized by a distinctive endoscopic appearance. The main treatment of GAVE is endoscopic; however, medication is necessary in refractory cases. We herein report a 69-year-ol...

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Autores principales: Matsumoto, Yuki, Hayashi, Haeru, Tahara, Koichiro, Yasuda, Takuya, Tsubouchi, Shoko, Yamamoto, Yusuke, Mizuuchi, Takahiro, Mori, Hiroaki, Sawada, Tetsuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367100/
https://www.ncbi.nlm.nih.gov/pubmed/30101944
http://dx.doi.org/10.2169/internalmedicine.1431-18
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author Matsumoto, Yuki
Hayashi, Haeru
Tahara, Koichiro
Yasuda, Takuya
Tsubouchi, Shoko
Yamamoto, Yusuke
Mizuuchi, Takahiro
Mori, Hiroaki
Sawada, Tetsuji
author_facet Matsumoto, Yuki
Hayashi, Haeru
Tahara, Koichiro
Yasuda, Takuya
Tsubouchi, Shoko
Yamamoto, Yusuke
Mizuuchi, Takahiro
Mori, Hiroaki
Sawada, Tetsuji
author_sort Matsumoto, Yuki
collection PubMed
description Gastric antral vascular ectasia (GAVE) is a rare cause of chronic gastric hemorrhaging and iron deficiency anemia and is characterized by a distinctive endoscopic appearance. The main treatment of GAVE is endoscopic; however, medication is necessary in refractory cases. We herein report a 69-year-old woman with systemic sclerosis (SSc) who developed recurrent severe anemia after endoscopic treatment of GAVE that was successfully managed using intravenous cyclophosphamide (IVCY). The recurrence of GAVE after discontinuation of IVCY was successfully managed using a combination of IVCY and endoscopic treatment, without blood transfusion. Long-term IVCY may be indicated for refractory GAVE associated with SSc.
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spelling pubmed-63671002019-02-08 Intravenous Cyclophosphamide for Gastric Antral Vascular Ectasia Associated with Systemic Sclerosis Refractory to Endoscopic Treatment: A Case Report and Review of the Pertinent Literature Matsumoto, Yuki Hayashi, Haeru Tahara, Koichiro Yasuda, Takuya Tsubouchi, Shoko Yamamoto, Yusuke Mizuuchi, Takahiro Mori, Hiroaki Sawada, Tetsuji Intern Med Case Report Gastric antral vascular ectasia (GAVE) is a rare cause of chronic gastric hemorrhaging and iron deficiency anemia and is characterized by a distinctive endoscopic appearance. The main treatment of GAVE is endoscopic; however, medication is necessary in refractory cases. We herein report a 69-year-old woman with systemic sclerosis (SSc) who developed recurrent severe anemia after endoscopic treatment of GAVE that was successfully managed using intravenous cyclophosphamide (IVCY). The recurrence of GAVE after discontinuation of IVCY was successfully managed using a combination of IVCY and endoscopic treatment, without blood transfusion. Long-term IVCY may be indicated for refractory GAVE associated with SSc. The Japanese Society of Internal Medicine 2018-08-10 2019-01-01 /pmc/articles/PMC6367100/ /pubmed/30101944 http://dx.doi.org/10.2169/internalmedicine.1431-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Matsumoto, Yuki
Hayashi, Haeru
Tahara, Koichiro
Yasuda, Takuya
Tsubouchi, Shoko
Yamamoto, Yusuke
Mizuuchi, Takahiro
Mori, Hiroaki
Sawada, Tetsuji
Intravenous Cyclophosphamide for Gastric Antral Vascular Ectasia Associated with Systemic Sclerosis Refractory to Endoscopic Treatment: A Case Report and Review of the Pertinent Literature
title Intravenous Cyclophosphamide for Gastric Antral Vascular Ectasia Associated with Systemic Sclerosis Refractory to Endoscopic Treatment: A Case Report and Review of the Pertinent Literature
title_full Intravenous Cyclophosphamide for Gastric Antral Vascular Ectasia Associated with Systemic Sclerosis Refractory to Endoscopic Treatment: A Case Report and Review of the Pertinent Literature
title_fullStr Intravenous Cyclophosphamide for Gastric Antral Vascular Ectasia Associated with Systemic Sclerosis Refractory to Endoscopic Treatment: A Case Report and Review of the Pertinent Literature
title_full_unstemmed Intravenous Cyclophosphamide for Gastric Antral Vascular Ectasia Associated with Systemic Sclerosis Refractory to Endoscopic Treatment: A Case Report and Review of the Pertinent Literature
title_short Intravenous Cyclophosphamide for Gastric Antral Vascular Ectasia Associated with Systemic Sclerosis Refractory to Endoscopic Treatment: A Case Report and Review of the Pertinent Literature
title_sort intravenous cyclophosphamide for gastric antral vascular ectasia associated with systemic sclerosis refractory to endoscopic treatment: a case report and review of the pertinent literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367100/
https://www.ncbi.nlm.nih.gov/pubmed/30101944
http://dx.doi.org/10.2169/internalmedicine.1431-18
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