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Hedgehog pathway permissive conditions allow generation of immortal cell lines from granule cells derived from cancerous and non-cancerous cerebellum
Cerebellar granule cell progenitors (GCPs) undergo proliferation in the post-natal cerebellum that is dependent on sonic hedgehog (SHH) signalling. Deregulated SHH signalling leads to type 2 medulloblastoma (MB). In this work, a novel cell culture protocol is described, which is suitable for the est...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Royal Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367140/ https://www.ncbi.nlm.nih.gov/pubmed/30958113 http://dx.doi.org/10.1098/rsob.180145 |