Deregulation of Circular RNAs in Cancer From the Perspectives of Aberrant Biogenesis, Transport and Removal

CircRNAs (circular RNAs) are a class of RNAs generated from circularization with multiple novel functions. Recent studies have revealed the aberrant expression and aberrant functions of circRNAs in various tumors; thus, circRNAs have been recognized as promising cancer biomarkers. However, the under...

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Detalles Bibliográficos
Autores principales: Wu, Qiongqiong, Li, Peiyao, Wu, Minghua, Liu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367250/
https://www.ncbi.nlm.nih.gov/pubmed/30774645
http://dx.doi.org/10.3389/fgene.2019.00016
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author Wu, Qiongqiong
Li, Peiyao
Wu, Minghua
Liu, Qiang
author_facet Wu, Qiongqiong
Li, Peiyao
Wu, Minghua
Liu, Qiang
author_sort Wu, Qiongqiong
collection PubMed
description CircRNAs (circular RNAs) are a class of RNAs generated from circularization with multiple novel functions. Recent studies have revealed the aberrant expression and aberrant functions of circRNAs in various tumors; thus, circRNAs have been recognized as promising cancer biomarkers. However, the underlying mechanisms behind their aberrant expression and functions remain unclear. In this review, we discuss at length the cancer-specific deregulation of circRNAs and the potential underlying aberrant events in circRNA biogenesis, localization and removal in cancer cells.
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spelling pubmed-63672502019-02-15 Deregulation of Circular RNAs in Cancer From the Perspectives of Aberrant Biogenesis, Transport and Removal Wu, Qiongqiong Li, Peiyao Wu, Minghua Liu, Qiang Front Genet Genetics CircRNAs (circular RNAs) are a class of RNAs generated from circularization with multiple novel functions. Recent studies have revealed the aberrant expression and aberrant functions of circRNAs in various tumors; thus, circRNAs have been recognized as promising cancer biomarkers. However, the underlying mechanisms behind their aberrant expression and functions remain unclear. In this review, we discuss at length the cancer-specific deregulation of circRNAs and the potential underlying aberrant events in circRNA biogenesis, localization and removal in cancer cells. Frontiers Media S.A. 2019-02-01 /pmc/articles/PMC6367250/ /pubmed/30774645 http://dx.doi.org/10.3389/fgene.2019.00016 Text en Copyright © 2019 Wu, Li, Wu and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Wu, Qiongqiong
Li, Peiyao
Wu, Minghua
Liu, Qiang
Deregulation of Circular RNAs in Cancer From the Perspectives of Aberrant Biogenesis, Transport and Removal
title Deregulation of Circular RNAs in Cancer From the Perspectives of Aberrant Biogenesis, Transport and Removal
title_full Deregulation of Circular RNAs in Cancer From the Perspectives of Aberrant Biogenesis, Transport and Removal
title_fullStr Deregulation of Circular RNAs in Cancer From the Perspectives of Aberrant Biogenesis, Transport and Removal
title_full_unstemmed Deregulation of Circular RNAs in Cancer From the Perspectives of Aberrant Biogenesis, Transport and Removal
title_short Deregulation of Circular RNAs in Cancer From the Perspectives of Aberrant Biogenesis, Transport and Removal
title_sort deregulation of circular rnas in cancer from the perspectives of aberrant biogenesis, transport and removal
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367250/
https://www.ncbi.nlm.nih.gov/pubmed/30774645
http://dx.doi.org/10.3389/fgene.2019.00016
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