Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines

In the development of vaccines, the ability to initiate both innate and subsequent adaptive immune responses need to be considered. Live attenuated vaccines achieve this naturally, while inactivated and sub-unit vaccines generally require additional help provided through delivery systems and/or adju...

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Autores principales: Ssemaganda, Aloysious, Giddam, Ashwini Kumar, Zaman, Mehfuz, Skwarczynski, Mariusz, Toth, Istvan, Stanisic, Danielle I., Good, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367261/
https://www.ncbi.nlm.nih.gov/pubmed/30774635
http://dx.doi.org/10.3389/fimmu.2019.00135
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author Ssemaganda, Aloysious
Giddam, Ashwini Kumar
Zaman, Mehfuz
Skwarczynski, Mariusz
Toth, Istvan
Stanisic, Danielle I.
Good, Michael F.
author_facet Ssemaganda, Aloysious
Giddam, Ashwini Kumar
Zaman, Mehfuz
Skwarczynski, Mariusz
Toth, Istvan
Stanisic, Danielle I.
Good, Michael F.
author_sort Ssemaganda, Aloysious
collection PubMed
description In the development of vaccines, the ability to initiate both innate and subsequent adaptive immune responses need to be considered. Live attenuated vaccines achieve this naturally, while inactivated and sub-unit vaccines generally require additional help provided through delivery systems and/or adjuvants. Liposomes present an attractive adjuvant/delivery system for antigens. Here, we review the key aspects of immunity against Plasmodium parasites, liposome design considerations and their current application in the development of a malaria vaccine.
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spelling pubmed-63672612019-02-15 Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines Ssemaganda, Aloysious Giddam, Ashwini Kumar Zaman, Mehfuz Skwarczynski, Mariusz Toth, Istvan Stanisic, Danielle I. Good, Michael F. Front Immunol Immunology In the development of vaccines, the ability to initiate both innate and subsequent adaptive immune responses need to be considered. Live attenuated vaccines achieve this naturally, while inactivated and sub-unit vaccines generally require additional help provided through delivery systems and/or adjuvants. Liposomes present an attractive adjuvant/delivery system for antigens. Here, we review the key aspects of immunity against Plasmodium parasites, liposome design considerations and their current application in the development of a malaria vaccine. Frontiers Media S.A. 2019-02-01 /pmc/articles/PMC6367261/ /pubmed/30774635 http://dx.doi.org/10.3389/fimmu.2019.00135 Text en Copyright © 2019 Ssemaganda, Giddam, Zaman, Skwarczynski, Toth, Stanisic and Good. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ssemaganda, Aloysious
Giddam, Ashwini Kumar
Zaman, Mehfuz
Skwarczynski, Mariusz
Toth, Istvan
Stanisic, Danielle I.
Good, Michael F.
Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines
title Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines
title_full Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines
title_fullStr Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines
title_full_unstemmed Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines
title_short Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines
title_sort induction of plasmodium-specific immune responses using liposome-based vaccines
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367261/
https://www.ncbi.nlm.nih.gov/pubmed/30774635
http://dx.doi.org/10.3389/fimmu.2019.00135
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