Unconventional secretion factor GRASP55 is increased by pharmacological unfolded protein response inducers in neurons

Accumulation of misfolded proteins in the endoplasmic reticulum (ER), defined as ER stress, results in activation of the unfolded protein response (UPR). UPR activation is commonly observed in neurodegenerative diseases. ER stress can trigger unconventional secretion mediated by Golgi reassembly and...

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Detalles Bibliográficos
Autores principales: van Ziel, Anna Maria, Largo-Barrientos, Pablo, Wolzak, Kimberly, Verhage, Matthijs, Scheper, Wiep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367349/
https://www.ncbi.nlm.nih.gov/pubmed/30733486
http://dx.doi.org/10.1038/s41598-018-38146-6

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