PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression

PTEN is a lipid phosphatase that antagonizes the PI3K/AKT pathway and is recognized as a major dose-dependent tumor suppressor. The cellular mechanisms that control PTEN levels therefore offer potential routes to therapy, but these are as yet poorly defined. Here we demonstrate that PTEN plays an un...

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Detalles Bibliográficos
Autores principales: Park, Mi Kyung, Yao, Yixin, Xia, Weiya, Setijono, Stephanie Rebecca, Kim, Jae Hwan, Vila, Isabelle K., Chiu, Hui-Hsuan, Wu, Yun, Billalabeitia, Enrique González, Lee, Min Gyu, Kalb, Robert G., Hung, Mien-Chie, Pandolfi, Pier Paolo, Song, Su Jung, Song, Min Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367354/
https://www.ncbi.nlm.nih.gov/pubmed/30733438
http://dx.doi.org/10.1038/s41467-019-08481-x

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