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Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium
The first step in the development of human colorectal cancer is aberrant activation of the Wnt signaling pathway. Wnt signaling hyperactivation is predominantly caused by loss-of-function mutations in the adenomatous polyposis coli (APC) gene that encodes the pathway negative regulator. In order to...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367488/ https://www.ncbi.nlm.nih.gov/pubmed/30733598 http://dx.doi.org/10.1038/s41598-018-38310-y |