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ImmunoSPdb: an archive of immunosuppressive peptides

Immunosuppression proved as a captivating therapy in several autoimmune disorders, asthma as well as in organ transplantation. Immunosuppressive peptides are specific for reducing efficacy of immune system with wide range of therapeutic implementations. `ImmunoSPdb’ is a comprehensive, manually cura...

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Detalles Bibliográficos
Autores principales: Usmani, Salman Sadullah, Agrawal, Piyush, Sehgal, Manika, Patel, Pradeep Kumar, Raghava, Gajendra P S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367516/
https://www.ncbi.nlm.nih.gov/pubmed/30753476
http://dx.doi.org/10.1093/database/baz012
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author Usmani, Salman Sadullah
Agrawal, Piyush
Sehgal, Manika
Patel, Pradeep Kumar
Raghava, Gajendra P S
author_facet Usmani, Salman Sadullah
Agrawal, Piyush
Sehgal, Manika
Patel, Pradeep Kumar
Raghava, Gajendra P S
author_sort Usmani, Salman Sadullah
collection PubMed
description Immunosuppression proved as a captivating therapy in several autoimmune disorders, asthma as well as in organ transplantation. Immunosuppressive peptides are specific for reducing efficacy of immune system with wide range of therapeutic implementations. `ImmunoSPdb’ is a comprehensive, manually curated database of around 500 experimentally verified immunosuppressive peptides compiled from 79 research article and 32 patents. The current version comprises of 553 entries providing extensive information including peptide name, sequence, chirality, chemical modification, origin, nature of peptide, its target as well as mechanism of action, amino acid frequency and composition, etc. Data analysis revealed that most of the immunosuppressive peptides are linear (91%), are shorter in length i.e. up to 20 amino acids (62%) and have L form of amino acids (81%). About 30% peptide are either chemically modified or have end terminal modification. Most of the peptides either are derived from proteins (41%) or naturally (27%) exist. Blockage of potassium ion channel (24%) is one a major target for immunosuppressive peptides. In addition, we have annotated tertiary structure by using PEPstrMOD and I-TASSER. Many user-friendly, web-based tools have been integrated to facilitate searching, browsing and analyzing the data. We have developed a user-friendly responsive website to assist a wide range of users.
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spelling pubmed-63675162019-02-20 ImmunoSPdb: an archive of immunosuppressive peptides Usmani, Salman Sadullah Agrawal, Piyush Sehgal, Manika Patel, Pradeep Kumar Raghava, Gajendra P S Database (Oxford) Database Tool Immunosuppression proved as a captivating therapy in several autoimmune disorders, asthma as well as in organ transplantation. Immunosuppressive peptides are specific for reducing efficacy of immune system with wide range of therapeutic implementations. `ImmunoSPdb’ is a comprehensive, manually curated database of around 500 experimentally verified immunosuppressive peptides compiled from 79 research article and 32 patents. The current version comprises of 553 entries providing extensive information including peptide name, sequence, chirality, chemical modification, origin, nature of peptide, its target as well as mechanism of action, amino acid frequency and composition, etc. Data analysis revealed that most of the immunosuppressive peptides are linear (91%), are shorter in length i.e. up to 20 amino acids (62%) and have L form of amino acids (81%). About 30% peptide are either chemically modified or have end terminal modification. Most of the peptides either are derived from proteins (41%) or naturally (27%) exist. Blockage of potassium ion channel (24%) is one a major target for immunosuppressive peptides. In addition, we have annotated tertiary structure by using PEPstrMOD and I-TASSER. Many user-friendly, web-based tools have been integrated to facilitate searching, browsing and analyzing the data. We have developed a user-friendly responsive website to assist a wide range of users. Oxford University Press 2019-02-08 /pmc/articles/PMC6367516/ /pubmed/30753476 http://dx.doi.org/10.1093/database/baz012 Text en © The Author(s) 2019. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Database Tool
Usmani, Salman Sadullah
Agrawal, Piyush
Sehgal, Manika
Patel, Pradeep Kumar
Raghava, Gajendra P S
ImmunoSPdb: an archive of immunosuppressive peptides
title ImmunoSPdb: an archive of immunosuppressive peptides
title_full ImmunoSPdb: an archive of immunosuppressive peptides
title_fullStr ImmunoSPdb: an archive of immunosuppressive peptides
title_full_unstemmed ImmunoSPdb: an archive of immunosuppressive peptides
title_short ImmunoSPdb: an archive of immunosuppressive peptides
title_sort immunospdb: an archive of immunosuppressive peptides
topic Database Tool
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367516/
https://www.ncbi.nlm.nih.gov/pubmed/30753476
http://dx.doi.org/10.1093/database/baz012
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