NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia

Transient Epileptic Amnesia (TEA) is a subtype of temporal lobe epilepsy, typically presenting in a person's early 60s, and of unknown aetiology. Encephalitis caused by antibodies to NMDA receptors (NMDARE) has not previously been documented in TEA. We describe a 47-year-old male who satisfied...

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Autores principales: Savage, Sharon A., Irani, Sarosh R., Leite, M. Isabel, Zeman, Adam Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier/North-Holland 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367595/
https://www.ncbi.nlm.nih.gov/pubmed/30686545
http://dx.doi.org/10.1016/j.jneuroim.2019.01.011
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author Savage, Sharon A.
Irani, Sarosh R.
Leite, M. Isabel
Zeman, Adam Z.
author_facet Savage, Sharon A.
Irani, Sarosh R.
Leite, M. Isabel
Zeman, Adam Z.
author_sort Savage, Sharon A.
collection PubMed
description Transient Epileptic Amnesia (TEA) is a subtype of temporal lobe epilepsy, typically presenting in a person's early 60s, and of unknown aetiology. Encephalitis caused by antibodies to NMDA receptors (NMDARE) has not previously been documented in TEA. We describe a 47-year-old male who satisfied criteria for TEA, but given his atypical symptoms, was also screened for autoimmune epilepsy. High levels of serum NMDAR antibodies were found, suggesting NMDARE. Immunosuppressive treatment gradually eliminated the NMDA receptor antibodies. Our case extends the clinical spectrum associated with neuronal cell-surface autoantibodies to include atypical cases of TEA.
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spelling pubmed-63675952019-02-15 NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia Savage, Sharon A. Irani, Sarosh R. Leite, M. Isabel Zeman, Adam Z. J Neuroimmunol Article Transient Epileptic Amnesia (TEA) is a subtype of temporal lobe epilepsy, typically presenting in a person's early 60s, and of unknown aetiology. Encephalitis caused by antibodies to NMDA receptors (NMDARE) has not previously been documented in TEA. We describe a 47-year-old male who satisfied criteria for TEA, but given his atypical symptoms, was also screened for autoimmune epilepsy. High levels of serum NMDAR antibodies were found, suggesting NMDARE. Immunosuppressive treatment gradually eliminated the NMDA receptor antibodies. Our case extends the clinical spectrum associated with neuronal cell-surface autoantibodies to include atypical cases of TEA. Elsevier/North-Holland 2019-02-15 /pmc/articles/PMC6367595/ /pubmed/30686545 http://dx.doi.org/10.1016/j.jneuroim.2019.01.011 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Savage, Sharon A.
Irani, Sarosh R.
Leite, M. Isabel
Zeman, Adam Z.
NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia
title NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia
title_full NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia
title_fullStr NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia
title_full_unstemmed NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia
title_short NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia
title_sort nmda receptor antibody encephalitis presenting as transient epileptic amnesia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367595/
https://www.ncbi.nlm.nih.gov/pubmed/30686545
http://dx.doi.org/10.1016/j.jneuroim.2019.01.011
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AT leitemisabel nmdareceptorantibodyencephalitispresentingastransientepilepticamnesia
AT zemanadamz nmdareceptorantibodyencephalitispresentingastransientepilepticamnesia

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