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Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia

BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is caused by bacteria that are resistant to the most effective anti-tuberculosis drug. The MDR-TB is an increasing global problem and the spread of MDR-TB has different recovery time for different patients. Therefore, this study aimed to investig...

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Autores principales: Limenih, Yigzaw Alemu, Workie, Demeke Lakew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367739/
https://www.ncbi.nlm.nih.gov/pubmed/30732601
http://dx.doi.org/10.1186/s12889-019-6500-3
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author Limenih, Yigzaw Alemu
Workie, Demeke Lakew
author_facet Limenih, Yigzaw Alemu
Workie, Demeke Lakew
author_sort Limenih, Yigzaw Alemu
collection PubMed
description BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is caused by bacteria that are resistant to the most effective anti-tuberculosis drug. The MDR-TB is an increasing global problem and the spread of MDR-TB has different recovery time for different patients. Therefore, this study aimed to investigate the recovery time of MDR-TB patients in Amhara region, Ethiopia. METHOD: A retrospective study was carried out in seven hospitals having MDR-TB treatment center of Amhara region, Ethiopia from September 2015 to February 2018. An accelerated failure time and parametric shared frailty models were employed. RESULTS: The study revealed that the recovery time of MDR-TB patients in Amhara region was 21 months. Out of the total MDR-TB patients, 110 (35.4%) censored and 201 (64.6%) cured of MDR-TB. The clustering effect of frailty model was hospitals and the Weibull-gamma shared frailty model was selected among all and hence used for this study. The study showed that extra pulmonary MDR-TB patients had longer recovery time than that of seamier pulmonary MDR-TB patients in Amhara region, Ethiopia. According to this study, male MDR-TB patients, MDR-TB patients with co-morbidity and clinical complication were experiencing longer recovery time than that of the counter groups. This study also showed that MDR-TB patients with poor adherence had longer recovery time than those with good adherence MDR-TB patients. CONCLUSION: Among different factors considered in this study, MDR-TB type, clinical complication, adherence, co-morbidities, sex, and smoking status had a significant effect on recovery time of MDR-TB patients in Amhara region, Ethiopia. In conclusion, the Regional and Federal Government of Ethiopia should take immediate steps to address causes of recovery time of MDR-TB patients in Amhara region through encouraging adherence, early case detection, and proper handling of drug-susceptibility according to WHO guidelines.
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spelling pubmed-63677392019-02-15 Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia Limenih, Yigzaw Alemu Workie, Demeke Lakew BMC Public Health Research Article BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is caused by bacteria that are resistant to the most effective anti-tuberculosis drug. The MDR-TB is an increasing global problem and the spread of MDR-TB has different recovery time for different patients. Therefore, this study aimed to investigate the recovery time of MDR-TB patients in Amhara region, Ethiopia. METHOD: A retrospective study was carried out in seven hospitals having MDR-TB treatment center of Amhara region, Ethiopia from September 2015 to February 2018. An accelerated failure time and parametric shared frailty models were employed. RESULTS: The study revealed that the recovery time of MDR-TB patients in Amhara region was 21 months. Out of the total MDR-TB patients, 110 (35.4%) censored and 201 (64.6%) cured of MDR-TB. The clustering effect of frailty model was hospitals and the Weibull-gamma shared frailty model was selected among all and hence used for this study. The study showed that extra pulmonary MDR-TB patients had longer recovery time than that of seamier pulmonary MDR-TB patients in Amhara region, Ethiopia. According to this study, male MDR-TB patients, MDR-TB patients with co-morbidity and clinical complication were experiencing longer recovery time than that of the counter groups. This study also showed that MDR-TB patients with poor adherence had longer recovery time than those with good adherence MDR-TB patients. CONCLUSION: Among different factors considered in this study, MDR-TB type, clinical complication, adherence, co-morbidities, sex, and smoking status had a significant effect on recovery time of MDR-TB patients in Amhara region, Ethiopia. In conclusion, the Regional and Federal Government of Ethiopia should take immediate steps to address causes of recovery time of MDR-TB patients in Amhara region through encouraging adherence, early case detection, and proper handling of drug-susceptibility according to WHO guidelines. BioMed Central 2019-02-07 /pmc/articles/PMC6367739/ /pubmed/30732601 http://dx.doi.org/10.1186/s12889-019-6500-3 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Limenih, Yigzaw Alemu
Workie, Demeke Lakew
Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia
title Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia
title_full Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia
title_fullStr Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia
title_full_unstemmed Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia
title_short Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia
title_sort survival analysis of time to cure on multi-drug resistance tuberculosis patients in amhara region, ethiopia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367739/
https://www.ncbi.nlm.nih.gov/pubmed/30732601
http://dx.doi.org/10.1186/s12889-019-6500-3
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