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Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia
BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is caused by bacteria that are resistant to the most effective anti-tuberculosis drug. The MDR-TB is an increasing global problem and the spread of MDR-TB has different recovery time for different patients. Therefore, this study aimed to investig...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367739/ https://www.ncbi.nlm.nih.gov/pubmed/30732601 http://dx.doi.org/10.1186/s12889-019-6500-3 |
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author | Limenih, Yigzaw Alemu Workie, Demeke Lakew |
author_facet | Limenih, Yigzaw Alemu Workie, Demeke Lakew |
author_sort | Limenih, Yigzaw Alemu |
collection | PubMed |
description | BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is caused by bacteria that are resistant to the most effective anti-tuberculosis drug. The MDR-TB is an increasing global problem and the spread of MDR-TB has different recovery time for different patients. Therefore, this study aimed to investigate the recovery time of MDR-TB patients in Amhara region, Ethiopia. METHOD: A retrospective study was carried out in seven hospitals having MDR-TB treatment center of Amhara region, Ethiopia from September 2015 to February 2018. An accelerated failure time and parametric shared frailty models were employed. RESULTS: The study revealed that the recovery time of MDR-TB patients in Amhara region was 21 months. Out of the total MDR-TB patients, 110 (35.4%) censored and 201 (64.6%) cured of MDR-TB. The clustering effect of frailty model was hospitals and the Weibull-gamma shared frailty model was selected among all and hence used for this study. The study showed that extra pulmonary MDR-TB patients had longer recovery time than that of seamier pulmonary MDR-TB patients in Amhara region, Ethiopia. According to this study, male MDR-TB patients, MDR-TB patients with co-morbidity and clinical complication were experiencing longer recovery time than that of the counter groups. This study also showed that MDR-TB patients with poor adherence had longer recovery time than those with good adherence MDR-TB patients. CONCLUSION: Among different factors considered in this study, MDR-TB type, clinical complication, adherence, co-morbidities, sex, and smoking status had a significant effect on recovery time of MDR-TB patients in Amhara region, Ethiopia. In conclusion, the Regional and Federal Government of Ethiopia should take immediate steps to address causes of recovery time of MDR-TB patients in Amhara region through encouraging adherence, early case detection, and proper handling of drug-susceptibility according to WHO guidelines. |
format | Online Article Text |
id | pubmed-6367739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63677392019-02-15 Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia Limenih, Yigzaw Alemu Workie, Demeke Lakew BMC Public Health Research Article BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is caused by bacteria that are resistant to the most effective anti-tuberculosis drug. The MDR-TB is an increasing global problem and the spread of MDR-TB has different recovery time for different patients. Therefore, this study aimed to investigate the recovery time of MDR-TB patients in Amhara region, Ethiopia. METHOD: A retrospective study was carried out in seven hospitals having MDR-TB treatment center of Amhara region, Ethiopia from September 2015 to February 2018. An accelerated failure time and parametric shared frailty models were employed. RESULTS: The study revealed that the recovery time of MDR-TB patients in Amhara region was 21 months. Out of the total MDR-TB patients, 110 (35.4%) censored and 201 (64.6%) cured of MDR-TB. The clustering effect of frailty model was hospitals and the Weibull-gamma shared frailty model was selected among all and hence used for this study. The study showed that extra pulmonary MDR-TB patients had longer recovery time than that of seamier pulmonary MDR-TB patients in Amhara region, Ethiopia. According to this study, male MDR-TB patients, MDR-TB patients with co-morbidity and clinical complication were experiencing longer recovery time than that of the counter groups. This study also showed that MDR-TB patients with poor adherence had longer recovery time than those with good adherence MDR-TB patients. CONCLUSION: Among different factors considered in this study, MDR-TB type, clinical complication, adherence, co-morbidities, sex, and smoking status had a significant effect on recovery time of MDR-TB patients in Amhara region, Ethiopia. In conclusion, the Regional and Federal Government of Ethiopia should take immediate steps to address causes of recovery time of MDR-TB patients in Amhara region through encouraging adherence, early case detection, and proper handling of drug-susceptibility according to WHO guidelines. BioMed Central 2019-02-07 /pmc/articles/PMC6367739/ /pubmed/30732601 http://dx.doi.org/10.1186/s12889-019-6500-3 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Limenih, Yigzaw Alemu Workie, Demeke Lakew Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia |
title | Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia |
title_full | Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia |
title_fullStr | Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia |
title_full_unstemmed | Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia |
title_short | Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia |
title_sort | survival analysis of time to cure on multi-drug resistance tuberculosis patients in amhara region, ethiopia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367739/ https://www.ncbi.nlm.nih.gov/pubmed/30732601 http://dx.doi.org/10.1186/s12889-019-6500-3 |
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