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Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis

BACKGROUND: Insulin-like Growth Factor Receptor-1 (IGF1R) system sustains the genesis of rhabdomyosarcoma through IGF2 autocrine overexpression. While several IGF1R-targeted strategies have been investigated to interphere with rhabdomyosarcoma growth, no attempt to neutralize IGF2 has been reported....

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Detalles Bibliográficos
Autores principales:	De Giovanni, Carla, Nanni, Patrizia, Landuzzi, Lorena, Ianzano, Marianna L., Nicoletti, Giordano, Croci, Stefania, Palladini, Arianna, Lollini, Pier-Luigi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367747/ https://www.ncbi.nlm.nih.gov/pubmed/30732578 http://dx.doi.org/10.1186/s12885-019-5339-4

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