Dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations potently inhibits acute myeloid leukemia cell lines

AIM: Approximately 30% of acute myeloid leukemia (AML) patients carry FLT3 tyrosine kinase domain (TKD) mutations or internal tandem duplication (FLT3-ITD). Currently there is a paucity of compounds that are active against drug-resistant FLT3-ITD, which contains secondary mutations in the TKD, mainl...

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Detalles Bibliográficos
Autores principales: Dayal, Neetu, Opoku-Temeng, Clement, Hernandez, Delmis E, Sooreshjani, Moloud Aflaki, Carter-Cooper, Brandon A, Lapidus, Rena G, Sintim, Herman O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367750/
https://www.ncbi.nlm.nih.gov/pubmed/29437468
http://dx.doi.org/10.4155/fmc-2017-0298

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