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Health-related quality of life varies in different respiratory disorders: a multi-case control population based study
BACKGROUND AND OBJECTIVE: Health-related quality of life (HRQL) in respiratory diseases has been generally investigated in clinical settings, focusing on a single disorder. In this study on a general population sample, we assessed the relationship between HRQL and several respiratory diseases studie...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367788/ https://www.ncbi.nlm.nih.gov/pubmed/30732605 http://dx.doi.org/10.1186/s12890-019-0796-8 |
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author | Cappa, Veronica Marcon, Alessandro Di Gennaro, Gianfranco Chamitava, Liliya Cazzoletti, Lucia Bombieri, Cristina Nicolis, Morena Perbellini, Luigi Sembeni, Silvia de Marco, Roberto Spelta, Francesco Ferrari, Marcello Zanolin, Maria Elisabetta |
author_facet | Cappa, Veronica Marcon, Alessandro Di Gennaro, Gianfranco Chamitava, Liliya Cazzoletti, Lucia Bombieri, Cristina Nicolis, Morena Perbellini, Luigi Sembeni, Silvia de Marco, Roberto Spelta, Francesco Ferrari, Marcello Zanolin, Maria Elisabetta |
author_sort | Cappa, Veronica |
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: Health-related quality of life (HRQL) in respiratory diseases has been generally investigated in clinical settings, focusing on a single disorder. In this study on a general population sample, we assessed the relationship between HRQL and several respiratory diseases studied simultaneously (COPD, current (CA) and past (PA) asthma, allergic (AR) and non-allergic (NAR) rhinitis and chronic bronchitis (CB). METHODS: Controls (n = 328) and cases of NAR (n = 95), AR (n = 163), CB (n = 48), CA (n = 224), PA (n = 126) and COPD (n = 28) were recruited in the centre of Verona in the frame of the Italian multi-case control GEIRD (Gene Environment Interactions in Respiratory Diseases) study; HRQL was measured through the SF-36 questionnaire. The relationships between HRQL (in terms of Physical (PCS) and Mental Component Scores (MCS)), respiratory diseases, and covariates were evaluated. RESULTS: With respect to controls, the adjusted PCS median score was worse in subjects suffering from current asthma (− 1.7; 95%CI:-2.8;-0.6), CB (− 3.8; 95%CI:-5.7;-1.9), and COPD (− 5.6; 95%CI:-8.1;-3.1). MCS was worse in current asthmatics (− 2.2; 95%CI:-4.1;-0.3), CB (− 5.5; 95%CI:-8.7;-2.2), and COPD cases (− 4.6; 95%CI:-8.8;-0.5) as well. CONCLUSIONS: To our knowledge, this is the first study in the general population that analyzed HRQL performing a simultaneous comparison of HRLQ in several respiratory disorders. We found that subjects suffering from COPD, CA, and CB had the poorest HRQL. Clinicians should carefully consider the possible impact of respiratory disorders as CB and not only that of CA and COPD. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12890-019-0796-8) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6367788 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63677882019-02-15 Health-related quality of life varies in different respiratory disorders: a multi-case control population based study Cappa, Veronica Marcon, Alessandro Di Gennaro, Gianfranco Chamitava, Liliya Cazzoletti, Lucia Bombieri, Cristina Nicolis, Morena Perbellini, Luigi Sembeni, Silvia de Marco, Roberto Spelta, Francesco Ferrari, Marcello Zanolin, Maria Elisabetta BMC Pulm Med Research Article BACKGROUND AND OBJECTIVE: Health-related quality of life (HRQL) in respiratory diseases has been generally investigated in clinical settings, focusing on a single disorder. In this study on a general population sample, we assessed the relationship between HRQL and several respiratory diseases studied simultaneously (COPD, current (CA) and past (PA) asthma, allergic (AR) and non-allergic (NAR) rhinitis and chronic bronchitis (CB). METHODS: Controls (n = 328) and cases of NAR (n = 95), AR (n = 163), CB (n = 48), CA (n = 224), PA (n = 126) and COPD (n = 28) were recruited in the centre of Verona in the frame of the Italian multi-case control GEIRD (Gene Environment Interactions in Respiratory Diseases) study; HRQL was measured through the SF-36 questionnaire. The relationships between HRQL (in terms of Physical (PCS) and Mental Component Scores (MCS)), respiratory diseases, and covariates were evaluated. RESULTS: With respect to controls, the adjusted PCS median score was worse in subjects suffering from current asthma (− 1.7; 95%CI:-2.8;-0.6), CB (− 3.8; 95%CI:-5.7;-1.9), and COPD (− 5.6; 95%CI:-8.1;-3.1). MCS was worse in current asthmatics (− 2.2; 95%CI:-4.1;-0.3), CB (− 5.5; 95%CI:-8.7;-2.2), and COPD cases (− 4.6; 95%CI:-8.8;-0.5) as well. CONCLUSIONS: To our knowledge, this is the first study in the general population that analyzed HRQL performing a simultaneous comparison of HRLQ in several respiratory disorders. We found that subjects suffering from COPD, CA, and CB had the poorest HRQL. Clinicians should carefully consider the possible impact of respiratory disorders as CB and not only that of CA and COPD. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12890-019-0796-8) contains supplementary material, which is available to authorized users. BioMed Central 2019-02-07 /pmc/articles/PMC6367788/ /pubmed/30732605 http://dx.doi.org/10.1186/s12890-019-0796-8 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Cappa, Veronica Marcon, Alessandro Di Gennaro, Gianfranco Chamitava, Liliya Cazzoletti, Lucia Bombieri, Cristina Nicolis, Morena Perbellini, Luigi Sembeni, Silvia de Marco, Roberto Spelta, Francesco Ferrari, Marcello Zanolin, Maria Elisabetta Health-related quality of life varies in different respiratory disorders: a multi-case control population based study |
title | Health-related quality of life varies in different respiratory disorders: a multi-case control population based study |
title_full | Health-related quality of life varies in different respiratory disorders: a multi-case control population based study |
title_fullStr | Health-related quality of life varies in different respiratory disorders: a multi-case control population based study |
title_full_unstemmed | Health-related quality of life varies in different respiratory disorders: a multi-case control population based study |
title_short | Health-related quality of life varies in different respiratory disorders: a multi-case control population based study |
title_sort | health-related quality of life varies in different respiratory disorders: a multi-case control population based study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367788/ https://www.ncbi.nlm.nih.gov/pubmed/30732605 http://dx.doi.org/10.1186/s12890-019-0796-8 |
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