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Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery

OBJECTIVE: To investigate the lung cancer-promoting mechanism of mesenchymal stem cell-secreted extracellular vesicles (MSC-EV). METHODS: EV were isolated from culture media of human bone marrow-derived MSCs that were pre-challenged with or without hypoxia (referred to as H-EV and N-EV, respectively...

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Detalles Bibliográficos
Autores principales:	Ren, Weihua, Hou, Jianfeng, Yang, Chenguang, Wang, Hanjun, Wu, Shuangting, Wu, Yabin, Zhao, Xingpeng, Lu, Chao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367822/ https://www.ncbi.nlm.nih.gov/pubmed/30736829 http://dx.doi.org/10.1186/s13046-019-1027-0

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