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Metastatic breast cancer incidence, site and survival in Australia, 2001–2016: a population-based health record linkage study protocol
INTRODUCTION: Advances in systemic therapy for early and metastatic breast cancer (BC) over the last two decades have improved patients’ survival, but their impact on metastatic disease outcomes at a population level is not well described. The aim of this study is to investigate changes in the incid...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367965/ https://www.ncbi.nlm.nih.gov/pubmed/30709862 http://dx.doi.org/10.1136/bmjopen-2018-026414 |
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author | Lord, Sarah J Kiely, Belinda E Pearson, Sallie-Anne Daniels, Benjamin O’Connell, Dianne L Beith, Jane Bulsara, Max K Houssami, Nehmat |
author_facet | Lord, Sarah J Kiely, Belinda E Pearson, Sallie-Anne Daniels, Benjamin O’Connell, Dianne L Beith, Jane Bulsara, Max K Houssami, Nehmat |
author_sort | Lord, Sarah J |
collection | PubMed |
description | INTRODUCTION: Advances in systemic therapy for early and metastatic breast cancer (BC) over the last two decades have improved patients’ survival, but their impact on metastatic disease outcomes at a population level is not well described. The aim of this study is to investigate changes in the incidence, site and survival of metastatic disease for women with a first diagnosis of BC in 2001–2002 vs 2006–2007. METHODS AND ANALYSIS: Population-based retrospective cohort study of women with first primary invasive BC registered in the New South Wales (NSW) Cancer Registry in 2001–2002 and 2006–2007. We will use linked records from NSW hospitals, dispensed medicines, outpatient services and death registrations to determine: women’s demographic and tumour characteristics; treatments received; time to first distant metastasis; site of first metastasis and survival. We will use the Kaplan-Meier method to estimate cumulative incidence of distant metastasis, distant recurrence-free interval and postmetastasis survival by extent of disease at initial diagnosis, site of metastasis and treatment-defined tumour receptor type (hormone receptor-positive, human epidermal growth factor receptor-2-positive, triple negative). We will use Cox proportional hazards regression to estimate the relative effects of prognostic factors, and we will compare systemic therapy patterns by area-of-residence and area-level socioeconomic status to examine equity of access to healthcare. ETHICS AND DISSEMINATION: Research ethics committee approval was granted by the Australian Institute of Health and Welfare (#EO2017/2/255), NSW Population and Health Services (#HREC/17/CIPHS/19) and University of Notre Dame Australia (#0 17 144S). We will disseminate research findings to oncology, BC consumer and epidemiology audiences through national and international conference presentations, lay summaries to BC consumer groups and publications in international peer-reviewed oncology and cancer epidemiology journals. |
format | Online Article Text |
id | pubmed-6367965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-63679652019-02-27 Metastatic breast cancer incidence, site and survival in Australia, 2001–2016: a population-based health record linkage study protocol Lord, Sarah J Kiely, Belinda E Pearson, Sallie-Anne Daniels, Benjamin O’Connell, Dianne L Beith, Jane Bulsara, Max K Houssami, Nehmat BMJ Open Oncology INTRODUCTION: Advances in systemic therapy for early and metastatic breast cancer (BC) over the last two decades have improved patients’ survival, but their impact on metastatic disease outcomes at a population level is not well described. The aim of this study is to investigate changes in the incidence, site and survival of metastatic disease for women with a first diagnosis of BC in 2001–2002 vs 2006–2007. METHODS AND ANALYSIS: Population-based retrospective cohort study of women with first primary invasive BC registered in the New South Wales (NSW) Cancer Registry in 2001–2002 and 2006–2007. We will use linked records from NSW hospitals, dispensed medicines, outpatient services and death registrations to determine: women’s demographic and tumour characteristics; treatments received; time to first distant metastasis; site of first metastasis and survival. We will use the Kaplan-Meier method to estimate cumulative incidence of distant metastasis, distant recurrence-free interval and postmetastasis survival by extent of disease at initial diagnosis, site of metastasis and treatment-defined tumour receptor type (hormone receptor-positive, human epidermal growth factor receptor-2-positive, triple negative). We will use Cox proportional hazards regression to estimate the relative effects of prognostic factors, and we will compare systemic therapy patterns by area-of-residence and area-level socioeconomic status to examine equity of access to healthcare. ETHICS AND DISSEMINATION: Research ethics committee approval was granted by the Australian Institute of Health and Welfare (#EO2017/2/255), NSW Population and Health Services (#HREC/17/CIPHS/19) and University of Notre Dame Australia (#0 17 144S). We will disseminate research findings to oncology, BC consumer and epidemiology audiences through national and international conference presentations, lay summaries to BC consumer groups and publications in international peer-reviewed oncology and cancer epidemiology journals. BMJ Publishing Group 2019-02-01 /pmc/articles/PMC6367965/ /pubmed/30709862 http://dx.doi.org/10.1136/bmjopen-2018-026414 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Oncology Lord, Sarah J Kiely, Belinda E Pearson, Sallie-Anne Daniels, Benjamin O’Connell, Dianne L Beith, Jane Bulsara, Max K Houssami, Nehmat Metastatic breast cancer incidence, site and survival in Australia, 2001–2016: a population-based health record linkage study protocol |
title | Metastatic breast cancer incidence, site and survival in Australia, 2001–2016: a population-based health record linkage study protocol |
title_full | Metastatic breast cancer incidence, site and survival in Australia, 2001–2016: a population-based health record linkage study protocol |
title_fullStr | Metastatic breast cancer incidence, site and survival in Australia, 2001–2016: a population-based health record linkage study protocol |
title_full_unstemmed | Metastatic breast cancer incidence, site and survival in Australia, 2001–2016: a population-based health record linkage study protocol |
title_short | Metastatic breast cancer incidence, site and survival in Australia, 2001–2016: a population-based health record linkage study protocol |
title_sort | metastatic breast cancer incidence, site and survival in australia, 2001–2016: a population-based health record linkage study protocol |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367965/ https://www.ncbi.nlm.nih.gov/pubmed/30709862 http://dx.doi.org/10.1136/bmjopen-2018-026414 |
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