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Do changes in weight status affect cognitive function in children and adolescents with obesity? A secondary analysis of a clinical trial

OBJECTIVES: It is unclear whether an association exists between obesity in children/adolescents and cognitive function, and whether the latter can be altered by body mass index (BMI) standard deviation score (SDS) reductions. We aimed to determine whether an association exists between BMI SDS and co...

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Autores principales: Anderson, Yvonne C, Kirkpatrick, Kaye, Dolan, Gerard M S, Wouldes, Trecia A, Grant, Cameron C, Cave, Tami L, Wild, Cervantée E K, Derraik, José G B, Cutfield, Wayne S, Hofman, Paul L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367974/
https://www.ncbi.nlm.nih.gov/pubmed/30782863
http://dx.doi.org/10.1136/bmjopen-2018-021586
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author Anderson, Yvonne C
Kirkpatrick, Kaye
Dolan, Gerard M S
Wouldes, Trecia A
Grant, Cameron C
Cave, Tami L
Wild, Cervantée E K
Derraik, José G B
Cutfield, Wayne S
Hofman, Paul L
author_facet Anderson, Yvonne C
Kirkpatrick, Kaye
Dolan, Gerard M S
Wouldes, Trecia A
Grant, Cameron C
Cave, Tami L
Wild, Cervantée E K
Derraik, José G B
Cutfield, Wayne S
Hofman, Paul L
author_sort Anderson, Yvonne C
collection PubMed
description OBJECTIVES: It is unclear whether an association exists between obesity in children/adolescents and cognitive function, and whether the latter can be altered by body mass index (BMI) standard deviation score (SDS) reductions. We aimed to determine whether an association exists between BMI SDS and cognitive function in children/adolescents with obesity engaged in an obesity intervention. Second, we sought to determine if BMI SDS reduction at 12 months was associated with improved cognitive function. DESIGN: Secondary analysis of a clinical trial. PARTICIPANTS: Participants (n=69) were recruited from an obesity intervention. Eligible participants (recruited June 2013 to June 2015) were aged 6–16 years, with a BMI ≥98th centile or BMI >91st centile with weight-related comorbidities. OUTCOME MEASURES: Primary outcome measure was change in BMI SDS from baseline at 12 months. Dependent variables of cognitive functioning and school achievement were assessed at baseline and 12 months, using dependent variables of cognitive functioning (elements of Ravens Standard Progressive Matrices, Wide Range Achievement Test-fourth edition and Wechsler Intelligence Scale for Children-fourth edition). RESULTS: At baseline, BMI SDS was not associated with all aspects of cognitive function tested (n=69). Reductions in BMI SDS over time did not alter cognitive function overall. However, there was a greater reduction in comprehension standard scores in participants who increased their BMI SDS (adjusted estimated difference −6.1, 95% CI −11.6 to −0.6; p=0.03). CONCLUSIONS: There were no observed associations between BMI SDS and cognitive function in participants, apart from comprehension in the exploratory analyses, which may have been a random finding. Further studies need to include larger longitudinal cohorts incorporating a wider BMI range at entry to determine whether our findings persist. TRIAL REGISTRATION NUMBER: ANZCTR12611000862943; Pre-results.
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spelling pubmed-63679742019-03-10 Do changes in weight status affect cognitive function in children and adolescents with obesity? A secondary analysis of a clinical trial Anderson, Yvonne C Kirkpatrick, Kaye Dolan, Gerard M S Wouldes, Trecia A Grant, Cameron C Cave, Tami L Wild, Cervantée E K Derraik, José G B Cutfield, Wayne S Hofman, Paul L BMJ Open Paediatrics OBJECTIVES: It is unclear whether an association exists between obesity in children/adolescents and cognitive function, and whether the latter can be altered by body mass index (BMI) standard deviation score (SDS) reductions. We aimed to determine whether an association exists between BMI SDS and cognitive function in children/adolescents with obesity engaged in an obesity intervention. Second, we sought to determine if BMI SDS reduction at 12 months was associated with improved cognitive function. DESIGN: Secondary analysis of a clinical trial. PARTICIPANTS: Participants (n=69) were recruited from an obesity intervention. Eligible participants (recruited June 2013 to June 2015) were aged 6–16 years, with a BMI ≥98th centile or BMI >91st centile with weight-related comorbidities. OUTCOME MEASURES: Primary outcome measure was change in BMI SDS from baseline at 12 months. Dependent variables of cognitive functioning and school achievement were assessed at baseline and 12 months, using dependent variables of cognitive functioning (elements of Ravens Standard Progressive Matrices, Wide Range Achievement Test-fourth edition and Wechsler Intelligence Scale for Children-fourth edition). RESULTS: At baseline, BMI SDS was not associated with all aspects of cognitive function tested (n=69). Reductions in BMI SDS over time did not alter cognitive function overall. However, there was a greater reduction in comprehension standard scores in participants who increased their BMI SDS (adjusted estimated difference −6.1, 95% CI −11.6 to −0.6; p=0.03). CONCLUSIONS: There were no observed associations between BMI SDS and cognitive function in participants, apart from comprehension in the exploratory analyses, which may have been a random finding. Further studies need to include larger longitudinal cohorts incorporating a wider BMI range at entry to determine whether our findings persist. TRIAL REGISTRATION NUMBER: ANZCTR12611000862943; Pre-results. BMJ Publishing Group 2019-02-03 /pmc/articles/PMC6367974/ /pubmed/30782863 http://dx.doi.org/10.1136/bmjopen-2018-021586 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Paediatrics
Anderson, Yvonne C
Kirkpatrick, Kaye
Dolan, Gerard M S
Wouldes, Trecia A
Grant, Cameron C
Cave, Tami L
Wild, Cervantée E K
Derraik, José G B
Cutfield, Wayne S
Hofman, Paul L
Do changes in weight status affect cognitive function in children and adolescents with obesity? A secondary analysis of a clinical trial
title Do changes in weight status affect cognitive function in children and adolescents with obesity? A secondary analysis of a clinical trial
title_full Do changes in weight status affect cognitive function in children and adolescents with obesity? A secondary analysis of a clinical trial
title_fullStr Do changes in weight status affect cognitive function in children and adolescents with obesity? A secondary analysis of a clinical trial
title_full_unstemmed Do changes in weight status affect cognitive function in children and adolescents with obesity? A secondary analysis of a clinical trial
title_short Do changes in weight status affect cognitive function in children and adolescents with obesity? A secondary analysis of a clinical trial
title_sort do changes in weight status affect cognitive function in children and adolescents with obesity? a secondary analysis of a clinical trial
topic Paediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367974/
https://www.ncbi.nlm.nih.gov/pubmed/30782863
http://dx.doi.org/10.1136/bmjopen-2018-021586
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