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PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY

INTRODUCTION: Gastric gastrointestinal tumors (GIST) are a rare and usually asymptomatic neoplasm that can present as abdominal mass in more advanced scenarios. Since surgical resection is the main aspect of the treatment, locally advanced tumors require multivisceral resection and, therefore, highe...

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Autores principales: RODRIGUES, João Bernardo Sancio Rocha, CAMPANATI, Renato Gomes, NOLASCO, Francisco, BERNARDES, Athos Miranda, SANCHES, Soraya Rodrigues de Almeida, SAVASSI-ROCHA, Paulo Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Colégio Brasileiro de Cirurgia Digestiva 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368167/
https://www.ncbi.nlm.nih.gov/pubmed/30758475
http://dx.doi.org/10.1590/0102-672020180001e1427
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author RODRIGUES, João Bernardo Sancio Rocha
CAMPANATI, Renato Gomes
NOLASCO, Francisco
BERNARDES, Athos Miranda
SANCHES, Soraya Rodrigues de Almeida
SAVASSI-ROCHA, Paulo Roberto
author_facet RODRIGUES, João Bernardo Sancio Rocha
CAMPANATI, Renato Gomes
NOLASCO, Francisco
BERNARDES, Athos Miranda
SANCHES, Soraya Rodrigues de Almeida
SAVASSI-ROCHA, Paulo Roberto
author_sort RODRIGUES, João Bernardo Sancio Rocha
collection PubMed
description INTRODUCTION: Gastric gastrointestinal tumors (GIST) are a rare and usually asymptomatic neoplasm that can present as abdominal mass in more advanced scenarios. Since surgical resection is the main aspect of the treatment, locally advanced tumors require multivisceral resection and, therefore, higher postoperative morbidity and mortality. OBJECTIVE: To perform a review the literature on the topic, with emphasis on the neoadjuvant therapy. METHODS: Literature review on the Medline database using the following descriptors: gastrointestinal stromal tumors, neoadjuvant therapy, imatinib mesylate and molecular targeted therapy. RESULTS: Surgical resection remains the cornerstone for the treatment of GISTs; however, tyrosine kinase inhibitors have improved survival as an adjuvant therapy. More recently, neoadjuvant therapy have been described in the treatment of locally advanced tumors in order to avoid multivisceral resection. CONCLUSION: Despite surgical resection remains as the most important aspect of the treatment of GISTs, adjuvant and neoadjuvant therapy with tyrosine kinase inhibitors have shown to both improve survival and resectability, respectively.
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spelling pubmed-63681672019-02-19 PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY RODRIGUES, João Bernardo Sancio Rocha CAMPANATI, Renato Gomes NOLASCO, Francisco BERNARDES, Athos Miranda SANCHES, Soraya Rodrigues de Almeida SAVASSI-ROCHA, Paulo Roberto Arq Bras Cir Dig Review Article INTRODUCTION: Gastric gastrointestinal tumors (GIST) are a rare and usually asymptomatic neoplasm that can present as abdominal mass in more advanced scenarios. Since surgical resection is the main aspect of the treatment, locally advanced tumors require multivisceral resection and, therefore, higher postoperative morbidity and mortality. OBJECTIVE: To perform a review the literature on the topic, with emphasis on the neoadjuvant therapy. METHODS: Literature review on the Medline database using the following descriptors: gastrointestinal stromal tumors, neoadjuvant therapy, imatinib mesylate and molecular targeted therapy. RESULTS: Surgical resection remains the cornerstone for the treatment of GISTs; however, tyrosine kinase inhibitors have improved survival as an adjuvant therapy. More recently, neoadjuvant therapy have been described in the treatment of locally advanced tumors in order to avoid multivisceral resection. CONCLUSION: Despite surgical resection remains as the most important aspect of the treatment of GISTs, adjuvant and neoadjuvant therapy with tyrosine kinase inhibitors have shown to both improve survival and resectability, respectively. Colégio Brasileiro de Cirurgia Digestiva 2019-02-07 /pmc/articles/PMC6368167/ /pubmed/30758475 http://dx.doi.org/10.1590/0102-672020180001e1427 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Review Article
RODRIGUES, João Bernardo Sancio Rocha
CAMPANATI, Renato Gomes
NOLASCO, Francisco
BERNARDES, Athos Miranda
SANCHES, Soraya Rodrigues de Almeida
SAVASSI-ROCHA, Paulo Roberto
PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY
title PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY
title_full PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY
title_fullStr PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY
title_full_unstemmed PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY
title_short PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY
title_sort pre-operative gastric gist downsizing: the importance of neoadjuvant therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368167/
https://www.ncbi.nlm.nih.gov/pubmed/30758475
http://dx.doi.org/10.1590/0102-672020180001e1427
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