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PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY
INTRODUCTION: Gastric gastrointestinal tumors (GIST) are a rare and usually asymptomatic neoplasm that can present as abdominal mass in more advanced scenarios. Since surgical resection is the main aspect of the treatment, locally advanced tumors require multivisceral resection and, therefore, highe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Colégio Brasileiro de Cirurgia Digestiva
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368167/ https://www.ncbi.nlm.nih.gov/pubmed/30758475 http://dx.doi.org/10.1590/0102-672020180001e1427 |
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author | RODRIGUES, João Bernardo Sancio Rocha CAMPANATI, Renato Gomes NOLASCO, Francisco BERNARDES, Athos Miranda SANCHES, Soraya Rodrigues de Almeida SAVASSI-ROCHA, Paulo Roberto |
author_facet | RODRIGUES, João Bernardo Sancio Rocha CAMPANATI, Renato Gomes NOLASCO, Francisco BERNARDES, Athos Miranda SANCHES, Soraya Rodrigues de Almeida SAVASSI-ROCHA, Paulo Roberto |
author_sort | RODRIGUES, João Bernardo Sancio Rocha |
collection | PubMed |
description | INTRODUCTION: Gastric gastrointestinal tumors (GIST) are a rare and usually asymptomatic neoplasm that can present as abdominal mass in more advanced scenarios. Since surgical resection is the main aspect of the treatment, locally advanced tumors require multivisceral resection and, therefore, higher postoperative morbidity and mortality. OBJECTIVE: To perform a review the literature on the topic, with emphasis on the neoadjuvant therapy. METHODS: Literature review on the Medline database using the following descriptors: gastrointestinal stromal tumors, neoadjuvant therapy, imatinib mesylate and molecular targeted therapy. RESULTS: Surgical resection remains the cornerstone for the treatment of GISTs; however, tyrosine kinase inhibitors have improved survival as an adjuvant therapy. More recently, neoadjuvant therapy have been described in the treatment of locally advanced tumors in order to avoid multivisceral resection. CONCLUSION: Despite surgical resection remains as the most important aspect of the treatment of GISTs, adjuvant and neoadjuvant therapy with tyrosine kinase inhibitors have shown to both improve survival and resectability, respectively. |
format | Online Article Text |
id | pubmed-6368167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Colégio Brasileiro de Cirurgia Digestiva |
record_format | MEDLINE/PubMed |
spelling | pubmed-63681672019-02-19 PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY RODRIGUES, João Bernardo Sancio Rocha CAMPANATI, Renato Gomes NOLASCO, Francisco BERNARDES, Athos Miranda SANCHES, Soraya Rodrigues de Almeida SAVASSI-ROCHA, Paulo Roberto Arq Bras Cir Dig Review Article INTRODUCTION: Gastric gastrointestinal tumors (GIST) are a rare and usually asymptomatic neoplasm that can present as abdominal mass in more advanced scenarios. Since surgical resection is the main aspect of the treatment, locally advanced tumors require multivisceral resection and, therefore, higher postoperative morbidity and mortality. OBJECTIVE: To perform a review the literature on the topic, with emphasis on the neoadjuvant therapy. METHODS: Literature review on the Medline database using the following descriptors: gastrointestinal stromal tumors, neoadjuvant therapy, imatinib mesylate and molecular targeted therapy. RESULTS: Surgical resection remains the cornerstone for the treatment of GISTs; however, tyrosine kinase inhibitors have improved survival as an adjuvant therapy. More recently, neoadjuvant therapy have been described in the treatment of locally advanced tumors in order to avoid multivisceral resection. CONCLUSION: Despite surgical resection remains as the most important aspect of the treatment of GISTs, adjuvant and neoadjuvant therapy with tyrosine kinase inhibitors have shown to both improve survival and resectability, respectively. Colégio Brasileiro de Cirurgia Digestiva 2019-02-07 /pmc/articles/PMC6368167/ /pubmed/30758475 http://dx.doi.org/10.1590/0102-672020180001e1427 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Review Article RODRIGUES, João Bernardo Sancio Rocha CAMPANATI, Renato Gomes NOLASCO, Francisco BERNARDES, Athos Miranda SANCHES, Soraya Rodrigues de Almeida SAVASSI-ROCHA, Paulo Roberto PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY |
title | PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY |
title_full | PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY |
title_fullStr | PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY |
title_full_unstemmed | PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY |
title_short | PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY |
title_sort | pre-operative gastric gist downsizing: the importance of neoadjuvant therapy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368167/ https://www.ncbi.nlm.nih.gov/pubmed/30758475 http://dx.doi.org/10.1590/0102-672020180001e1427 |
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