Characterization and dynamics of specific T cells against nucleophosmin-1 (NPM1)-mutated peptides in patients with NPM1-mutated acute myeloid leukemia

Nucleophosmin(NPM1)-mutated protein, a leukemia-specific antigen, represents an ideal target for AML immunotherapy. We investigated the dynamics of NPM1-mutated-specific T cells on PB and BM samples, collected from 31 adult NPM1-mutated AML patients throughout the disease course, and stimulated with...

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Detalles Bibliográficos
Autores principales: Forghieri, Fabio, Riva, Giovanni, Lagreca, Ivana, Barozzi, Patrizia, Vallerini, Daniela, Morselli, Monica, Paolini, Ambra, Bresciani, Paola, Colaci, Elisabetta, Maccaferri, Monica, Gilioli, Andrea, Nasillo, Vincenzo, Messerotti, Andrea, Pioli, Valeria, Arletti, Laura, Giusti, Davide, Bettelli, Francesca, Celli, Melania, Donatelli, Francesca, Corradini, Giorgia, Basso, Sabrina, Gurrado, Antonella, Cellini, Monica, Trenti, Tommaso, Marasca, Roberto, Narni, Franco, Martelli, Maria Paola, Falini, Brunangelo, Potenza, Leonardo, Luppi, Mario, Comoli, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368236/
https://www.ncbi.nlm.nih.gov/pubmed/30783516
http://dx.doi.org/10.18632/oncotarget.26617

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