Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability

Palmitoylation is an important posttranslational modification regulating diverse cellular functions. Consequently, aberrant palmitoylation can lead to diseases such as neuronal disorders or cancer. In humans there are roughly one hundred times more palmitoylated proteins than enzymes catalyzing palm...

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Autores principales: Strassburger, Katrin, Kang, Evangeline, Teleman, Aurelio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368284/
https://www.ncbi.nlm.nih.gov/pubmed/30735487
http://dx.doi.org/10.1371/journal.pone.0198149
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author Strassburger, Katrin
Kang, Evangeline
Teleman, Aurelio A.
author_facet Strassburger, Katrin
Kang, Evangeline
Teleman, Aurelio A.
author_sort Strassburger, Katrin
collection PubMed
description Palmitoylation is an important posttranslational modification regulating diverse cellular functions. Consequently, aberrant palmitoylation can lead to diseases such as neuronal disorders or cancer. In humans there are roughly one hundred times more palmitoylated proteins than enzymes catalyzing palmitoylation (palmitoyltransferases). Therefore, it is an important challenge to establish the links between palmitoyltransferases and their targets. From publicly available data, we find that expression of human ZDHHC8 correlates significantly with cancer survival. To elucidate the organismal function of ZDHHC8, we study the Drosophila ortholog of hZDHHC8, CG34449/dZDHHC8. Knockdown of dZDHHC8 causes tissue overgrowth while dZDHHC8 mutants are larval lethal. We provide a list of 159 palmitoylated proteins in Drosophila and present data suggesting that scribble and Ras64B are targets of dZDHHC8.
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spelling pubmed-63682842019-02-22 Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability Strassburger, Katrin Kang, Evangeline Teleman, Aurelio A. PLoS One Research Article Palmitoylation is an important posttranslational modification regulating diverse cellular functions. Consequently, aberrant palmitoylation can lead to diseases such as neuronal disorders or cancer. In humans there are roughly one hundred times more palmitoylated proteins than enzymes catalyzing palmitoylation (palmitoyltransferases). Therefore, it is an important challenge to establish the links between palmitoyltransferases and their targets. From publicly available data, we find that expression of human ZDHHC8 correlates significantly with cancer survival. To elucidate the organismal function of ZDHHC8, we study the Drosophila ortholog of hZDHHC8, CG34449/dZDHHC8. Knockdown of dZDHHC8 causes tissue overgrowth while dZDHHC8 mutants are larval lethal. We provide a list of 159 palmitoylated proteins in Drosophila and present data suggesting that scribble and Ras64B are targets of dZDHHC8. Public Library of Science 2019-02-08 /pmc/articles/PMC6368284/ /pubmed/30735487 http://dx.doi.org/10.1371/journal.pone.0198149 Text en © 2019 Strassburger et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Strassburger, Katrin
Kang, Evangeline
Teleman, Aurelio A.
Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability
title Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability
title_full Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability
title_fullStr Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability
title_full_unstemmed Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability
title_short Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability
title_sort drosophila zdhhc8 palmitoylates scribble and ras64b and controls growth and viability
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368284/
https://www.ncbi.nlm.nih.gov/pubmed/30735487
http://dx.doi.org/10.1371/journal.pone.0198149
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