Didehydro-Cortistatin A Inhibits HIV-1 by Specifically Binding to the Unstructured Basic Region of Tat

The intrinsically disordered HIV-1 Tat protein binds the viral RNA transactivation response structure (TAR), which recruits transcriptional cofactors, amplifying viral mRNA expression. Limited Tat transactivation correlates with HIV-1 latency. Unfortunately, Tat inhibitors are not clinically availab...

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Detalles Bibliográficos
Autores principales: Mediouni, Sonia, Chinthalapudi, Krishna, Ekka, Mary K., Usui, Ippei, Jablonski, Joseph A., Clementz, Mark A., Mousseau, Guillaume, Nowak, Jason, Macherla, Venkat R., Beverage, Jacob N., Esquenazi, Eduardo, Baran, Phil, de Vera, Ian Mitchelle S., Kojetin, Douglas, Loret, Erwann P., Nettles, Kendall, Maiti, Souvik, Izard, Tina, Valente, Susana T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368365/
https://www.ncbi.nlm.nih.gov/pubmed/30723126
http://dx.doi.org/10.1128/mBio.02662-18

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