CIC protein instability contributes to tumorigenesis in glioblastoma

Capicua (CIC) is a transcriptional repressor that counteracts activation of genes downstream of receptor tyrosine kinase (RTK)/Ras/ERK signaling. It is well-established that tumorigenesis, especially in glioblastoma (GBM), is attributed to hyperactive RTK/Ras/ERK signaling. While CIC is mutated in o...

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Detalles Bibliográficos
Autores principales: Bunda, Severa, Heir, Pardeep, Metcalf, Julie, Li, Annie Si Cong, Agnihotri, Sameer, Pusch, Stefan, Yasin, Mamatjan, Li, Mira, Burrell, Kelly, Mansouri, Sheila, Singh, Olivia, Wilson, Mark, Alamsahebpour, Amir, Nejad, Romina, Choi, Bethany, Kim, David, von Deimling, Andreas, Zadeh, Gelareh, Aldape, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368580/
https://www.ncbi.nlm.nih.gov/pubmed/30737375
http://dx.doi.org/10.1038/s41467-018-08087-9

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