Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies

Somatic mutations within antibody variable and framework regions (FWR) can alter thermostability and structural flexibility, but their impact on functional potency is unclear. Here we study thermostability and use molecular dynamics (MD) simulations to assess the role of FWR mutations during maturat...

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Detalles Bibliográficos
Autores principales: Henderson, Rory, Watts, Brian E., Ergin, Hieu N., Anasti, Kara, Parks, Robert, Xia, Shi-Mao, Trama, Ashley, Liao, Hua-Xin, Saunders, Kevin O., Bonsignori, Mattia, Wiehe, Kevin, Haynes, Barton F., Alam, S. Munir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368608/
https://www.ncbi.nlm.nih.gov/pubmed/30737386
http://dx.doi.org/10.1038/s41467-019-08415-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368608/
https://www.ncbi.nlm.nih.gov/pubmed/30737386
http://dx.doi.org/10.1038/s41467-019-08415-7

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