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Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions
How innate T cells (ITC), including invariant natural killer T (iNKT) cells, mucosal-associated invariant T (MAIT) cells, and γδ T cells, maintain a poised effector state has been unclear. Here we address this question using low-input and single-cell RNA-seq of human lymphocyte populations. Unbiased...
Autores principales: | Gutierrez-Arcelus, Maria, Teslovich, Nikola, Mola, Alex R., Polidoro, Rafael B., Nathan, Aparna, Kim, Hyun, Hannes, Susan, Slowikowski, Kamil, Watts, Gerald F. M., Korsunsky, Ilya, Brenner, Michael B., Raychaudhuri, Soumya, Brennan, Patrick J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368609/ https://www.ncbi.nlm.nih.gov/pubmed/30737409 http://dx.doi.org/10.1038/s41467-019-08604-4 |
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