Modeling double strand break susceptibility to interrogate structural variation in cancer

BACKGROUND: Structural variants (SVs) are known to play important roles in a variety of cancers, but their origins and functional consequences are still poorly understood. Many SVs are thought to emerge from errors in the repair processes following DNA double strand breaks (DSBs). RESULTS: We used e...

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Detalles Bibliográficos
Autores principales: Ballinger, Tracy J., Bouwman, Britta A. M., Mirzazadeh, Reza, Garnerone, Silvano, Crosetto, Nicola, Semple, Colin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368699/
https://www.ncbi.nlm.nih.gov/pubmed/30736820
http://dx.doi.org/10.1186/s13059-019-1635-1

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